Q9GKR7

PR
Gene name
IQCG (DRC9)
Protein name
Dynein regulatory complex protein 9
Names
IQ domain-containing protein G
Species
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-159 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9GKR7

Entry ID Method Resolution Chain Position Source
AF-Q9GKR7-F1 Predicted AlphaFoldDB

No variants for Q9GKR7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9GKR7

No associated diseases with Q9GKR7

1 regional properties for Q9GKR7

Type Name Position InterPro Accession
binding_site IQ motif, EF-hand binding site 393 - 422 IPR000048

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell projection, cilium, flagellum
  • Cell projection, cilium
  • Cytoplasm, cytoskeleton
  • Cytoplasm, cytoskeleton, flagellum axoneme
  • First detected in the cytoplasm of pachytene spermatocytes
  • Colocalizes with alpha-tubulin at the manchette in developing spermatids
  • Detected in the flagellum of mature testicular spermatozoa, and in the flagellum and post-acrosomal region of the head of epididymal spermatozoa
  • Detected in cilia in trachea and oviduct
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
manchette A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments.
motile cilium A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
sperm flagellum A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid.

1 GO annotations of molecular function

Name Definition
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.

2 GO annotations of biological process

Name Definition
sperm axoneme assembly The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement.
spermatid development The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEEDSQEDSN LPPKVWHSEM TVSVTGKPPS TVEEDGLPKE TDVETIPEIL ETREPLSLPD
70 80 90 100 110 120
VLRISAVLED TTDQLSILNY IMPIQYEGRQ SVCVKSREMN LEGKNLDKLP VASTVTKTPS
130 140 150 160 170 180
PLITKERPSL PEIRQGGQFA VEFCKTQDLL FKKPARQTIM TTETLKKIQI DRQFFSDVIA
190 200 210 220 230 240
DTIEELQDSG TYNSLLQALS KERENKMHFY DVIAREEKGR KQIISLQKQL INVKKEWQFE
250 260 270 280 290 300
VQSQNEYIAN LKDQLQEMKA KSNLENRYMK TNTELQIAQT QRKCNRTEEV LLEEIEKLRM
310 320 330 340 350 360
KTEEEARIHM DIEMFLRKQQ QKLEERLEFW MEKYDKDTEM KQNELNALKA TKASDLAHLQ
370 380 390 400 410 420
DLAKTIRECE QVIIEDRIEK EKSKNKIEQD LLELKSVIKL QAWWRGTMIR REIGGFKMPK
430 440
DKVDSKDSKG KGKGKDKRRG KKK