AiPD: Autoinhibited Protein Database

Gene name	PEX14 (PED2, At5g62810, MQB2.13)
Protein name	Peroxisomal membrane protein PEX14
Names	Peroxin-14, AtPEX14, Peroxisome biogenesis protein 14, Pex14p, Protein PEROXISOME DEFECTIVE 2
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT5G62810
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-76 (Predicted disordered autoinhibitory region) PR

1-76 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9FXT6-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH09560190	14	P>S	No	1000Genomes
ENSVATH09560190	14	P>T	No	1000Genomes
ENSVATH00748473	15	A>V	No	1000Genomes
tmp_5_25220377_G_A	19	E>K	No	1000Genomes
ENSVATH03466217	45	S>F	No	1000Genomes
tmp_5_25220735_G_A	46	V>M	No	1000Genomes
ENSVATH03466218	52	P>T	No	1000Genomes
ENSVATH03466222	67	H>N	No	1000Genomes
ENSVATH12910685	76	I>V	No	1000Genomes
tmp_5_25221007_C_T	109	T>I	No	1000Genomes
ENSVATH14646093	112	T>A	No	1000Genomes
tmp_5_25221125_G_A	119	A>T	No	1000Genomes
ENSVATH00748474	120	V>L	No	1000Genomes
tmp_5_25221186_T_C	139	I>T	No	1000Genomes
ENSVATH07470026	149	R>W	No	1000Genomes
ENSVATH00748475	151	R>C	No	1000Genomes
ENSVATH07470027	163	A>T	No	1000Genomes
tmp_5_25221737_T_A	181	F>Y	No	1000Genomes
ENSVATH03466236	237	E>G	No	1000Genomes
tmp_5_25222037_G_A	239	R>K	No	1000Genomes
ENSVATH07470036	266	L>R	No	1000Genomes
ENSVATH07470039	271	N>D	No	1000Genomes
ENSVATH07470040	289	T>P	No	1000Genomes
ENSVATH07470043	297	N>S	No	1000Genomes
ENSVATH03466242	305	T>I	No	1000Genomes
tmp_5_25222674_C_T	322	A>V	No	1000Genomes
tmp_5_25222984_C_T	355	P>L	No	1000Genomes
ENSVATH07470054	361	D>H	No	1000Genomes
tmp_5_25223023_C_T	368	S>L	No	1000Genomes
tmp_5_25223192_C_T	382	S>F	No	1000Genomes
ENSVATH12910740	406	R>H	No	1000Genomes
tmp_5_25223290_A_G	415	S>G	No	1000Genomes
tmp_5_25223362_G_A	439	A>T	No	1000Genomes
tmp_5_25223367_A_T	440	E>D	No	1000Genomes
ENSVATH00748481	442	V>A	No	1000Genomes
tmp_5_25223434_G_T	463	G>C	No	1000Genomes
ENSVATH07470059	476	K>R	No	1000Genomes
ENSVATH03466257	489	K>M	No	1000Genomes
ENSVATH03466258	491	A>T	No	1000Genomes
tmp_5_25223535_A_T	496	E>D	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Peroxisome membrane anchor protein Pex14p, N-terminal	54 - 98	IPR006785

		Description
EC Number
Subcellular Localization	Peroxisome membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
peroxisomal importomer complex	A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners.
peroxisomal membrane	The lipid bilayer surrounding a peroxisome.
peroxisome	A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
plastid	Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.

Name	Definition
signaling receptor binding	Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

Name	Definition
peroxisome organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.
protein import into peroxisome matrix, docking	The process in which a complex formed of a peroxisome targeting sequence (PTS) receptor bound to a PTS-bearing protein docks with translocation machinery in the peroxisomal membrane.
protein targeting to peroxisome	The process of directing proteins towards the peroxisome, usually using signals contained within the protein.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins