Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q9FVU0

Entry ID Method Resolution Chain Position Source
AF-Q9FVU0-F1 Predicted AlphaFoldDB

26 variants for Q9FVU0

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_21342881_C_T 7 P>S No 1000Genomes
ENSVATH14339105 9 T>A No 1000Genomes
ENSVATH04983392 14 A>S No 1000Genomes
ENSVATH01383859 17 F>S No 1000Genomes
ENSVATH01383860 18 S>F No 1000Genomes
tmp_1_21342917_C_G 19 L>V No 1000Genomes
ENSVATH04983394 20 S>L No 1000Genomes
ENSVATH04983395 23 C>Y No 1000Genomes
ENSVATH01383863 50 A>G No 1000Genomes
ENSVATH13609297 57 E>A No 1000Genomes
tmp_1_21343055_G_C,A 65 V>I No 1000Genomes
tmp_1_21343055_G_C,A 65 V>L No 1000Genomes
ENSVATH04983426 79 H>N No 1000Genomes
tmp_1_21343990_A_G 81 E>G No 1000Genomes
ENSVATH13609327 83 T>A No 1000Genomes
tmp_1_21344054_T_A 102 F>L No 1000Genomes
ENSVATH13609328 106 A>P No 1000Genomes
tmp_1_21344071_G_C 108 S>T No 1000Genomes
tmp_1_21344317_A_G 153 E>G No 1000Genomes
tmp_1_21344316_G_A 153 E>K No 1000Genomes
tmp_1_21344441_G_T,A 167 A>S No 1000Genomes
tmp_1_21344441_G_T,A 167 A>T No 1000Genomes
tmp_1_21344498_A_C 186 M>L No 1000Genomes
tmp_1_21344523_T_C 194 V>A No 1000Genomes
ENSVATH00102198 199 I>V No 1000Genomes
ENSVATH13609333 204 Q>L No 1000Genomes

No associated diseases with Q9FVU0

1 regional properties for Q9FVU0

Type Name Position InterPro Accession
domain GOLD domain 25 - 207 IPR009038

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane; Single-pass type I membrane protein
  • Golgi apparatus membrane; Single-pass type I membrane protein
  • Cycles between the endoplasmic reticulum and Golgi via COPI and COPII dependent pathways
  • Mainly located in endoplasmic reticulum
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
COPII-coated ER to Golgi transport vesicle A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport).
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
endoplasmic reticulum-Golgi intermediate compartment A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
endoplasmic reticulum to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
Golgi organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKKKMIPTTI LLSALIFSLS PICEAVWLTV PHTGSKCVSE EIQSNVIVLA DYLVISEEHS
70 80 90 100 110 120
IFPTVSVKVT APYGTVLHHR ENTTNGQFAF TTQESGTYLA CFEADAKSHG NKDFSINIDW
130 140 150 160 170 180
KTGIAAKDWD SIARKEKIEG VELEFKKLEG AVEAIHENLI YLRNREAEMR IVSEKTNSRV
190 200 210
AWYSIMSLGI CIVVSGLQIL YLKQYFEKKK LI