Q9FR82

PR
Gene name
sld1
Protein name
Delta(8)-fatty-acid desaturase
Names
Delta(8)-sphingolipid desaturase, Sphingolipid 8-(E/Z)-desaturase
Species
Borago officinalis (Bourrache) (Borage)
KEGG Pathway
EC number
1.14.19.29: With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

54-133 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9FR82

Entry ID Method Resolution Chain Position Source
AF-Q9FR82-F1 Predicted AlphaFoldDB

No variants for Q9FR82

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9FR82

No associated diseases with Q9FR82

2 regional properties for Q9FR82

Type Name Position InterPro Accession
domain Cytochrome b5-like heme/steroid binding domain 5 - 89 IPR001199
domain Fatty acid desaturase domain 136 - 406 IPR005804

Functions

Description
EC Number 1.14.19.29 With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
sphingolipid delta-8 desaturase activity Catalysis of the formation of a double bond between C8 and C9 of the long chain base of a sphingolipid. For example, sphinganine (d18:0) = 8-sphingenine (d18:1delta8); phytosphinganine (t18:0) = 8-phytosphingenine (t18:1delta8); and 4-sphingenine (18:1delta4) = 4,8-sphingadienine (d18:2delta4,8).

1 GO annotations of biological process

Name Definition
sphingolipid metabolic process The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEGTKKYISV GELEKHNQLG DVWISIQGKV YNVTDWIKKH PGGDVPIMNL AGQDATDAFI
70 80 90 100 110 120
AYHPGTAWKN LENLFTGYHL EDYLVSEISK DYRKLASEFS KAGLFEKKGH TVIYCLSFIA
130 140 150 160 170 180
LLLCGCVYGV LCSNSLWVHM LSGAMLGMCF IQAAYLGHDS GHYTMMSSKG YNKFAQVLNG
190 200 210 220 230 240
NCLTGISIAW WKWTHNAHHI ACNSLDYDPD LQHLPVFAVP SSFFKSLTSR FYGRELTFDG
250 260 270 280 290 300
LSRFLVSYQH FTIYLVMIFG RINLYVQTFL LLFSTRKVPD RALNIIGILV YWTWFPYLVS
310 320 330 340 350 360
CLPNWNERVL FVLTCFSVTA LQHIQFTLNH FAADVYVGPP TGTNWFEKQA AGTIDISCSS
370 380 390 400 410 420
WMDWFFGGLQ FQLEHHLFPR MPRCQLRNIS PIVQDYCKKH NLPYRSLSFF DANVATIKTL
430 440
RTAALQARDL TVVPQNLLWE AFNTHG