Q9FQ02
PR
Gene name |
XRN2 |
Protein name |
5'-3' exoribonuclease 2 |
Names |
AtXRN2, Protein EXORIBONUCLEASE 2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G42540 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9FQ02
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9FQ02-F1 | Predicted | AlphaFoldDB |
98 variants for Q9FQ02
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH03322291 | 17 | T>S | No | 1000Genomes | |
| ENSVATH07302728 | 18 | I>T | No | 1000Genomes | |
| ENSVATH03322294 | 27 | L>F | No | 1000Genomes | |
| ENSVATH03322294 | 27 | L>V | No | 1000Genomes | |
| ENSVATH03322295 | 28 | E>D | No | 1000Genomes | |
| ENSVATH12380083 | 31 | G>D | No | 1000Genomes | |
| ENSVATH12380135 | 36 | I>F | No | 1000Genomes | |
| ENSVATH03322297 | 40 | S>T | No | 1000Genomes | |
| ENSVATH12380136 | 51 | D>Y | No | 1000Genomes | |
| ENSVATH03322299 | 70 | K>R | No | 1000Genomes | |
| ENSVATH07302729 | 71 | P>S | No | 1000Genomes | |
| ENSVATH07302730 | 76 | F>Y | No | 1000Genomes | |
| ENSVATH07302731 | 81 | Q>H | No | 1000Genomes | |
| tmp_5_17008492_G_C | 139 | E>Q | No | 1000Genomes | |
| ENSVATH14568665 | 141 | F>L | No | 1000Genomes | |
| tmp_5_17008540_C_G | 155 | Q>E | No | 1000Genomes | |
| tmp_5_17008547_T_A | 157 | F>Y | No | 1000Genomes | |
| tmp_5_17008607_G_A | 177 | R>Q | No | 1000Genomes | |
| tmp_5_17008625_G_A | 183 | R>K | No | 1000Genomes | |
| tmp_5_17008653_T_A | 192 | N>K | No | 1000Genomes | |
| tmp_5_17008651_A_T | 192 | N>Y | No | 1000Genomes | |
| ENSVATH12380206 | 194 | K>M | No | 1000Genomes | |
| ENSVATH12380207 | 227 | T>I | No | 1000Genomes | |
| tmp_5_17009026_T_C | 248 | I>T | No | 1000Genomes | |
| ENSVATH07302762 | 290 | M>I | No | 1000Genomes | |
| ENSVATH07302764 | 354 | L>F | No | 1000Genomes | |
| tmp_5_17010152_A_G | 380 | T>A | No | 1000Genomes | |
| ENSVATH14568673 | 386 | N>I | No | 1000Genomes | |
| ENSVATH07302783 | 416 | S>A | No | 1000Genomes | |
| ENSVATH07302785 | 420 | R>H | No | 1000Genomes | |
| ENSVATH03322330 | 427 | K>N | No | 1000Genomes | |
| tmp_5_17010999_G_A | 429 | R>H | No | 1000Genomes | |
| ENSVATH08545944 | 437 | Q>R | No | 1000Genomes | |
| ENSVATH03322332 | 455 | V>L | No | 1000Genomes | |
| ENSVATH12380279 | 456 | S>F | No | 1000Genomes | |
| tmp_5_17011118_C_T | 469 | R>C | No | 1000Genomes | |
| ENSVATH00696798 | 475 | N>D | No | 1000Genomes | |
| tmp_5_17011149_C_T | 479 | A>V | No | 1000Genomes | |
| tmp_5_17011402_A_G | 501 | K>E | No | 1000Genomes | |
| ENSVATH12380282 | 505 | L>Q | No | 1000Genomes | |
| ENSVATH12380284 | 507 | R>Q | No | 1000Genomes | |
| ENSVATH03322335 | 512 | G>V | No | 1000Genomes | |
| ENSVATH12380305 | 516 | G>R | No | 1000Genomes | |
| tmp_5_17011611_A_C | 526 | N>H | No | 1000Genomes | |
| tmp_5_17011686_C_A | 551 | R>S | No | 1000Genomes | |
| ENSVATH12380306 | 552 | R>G | No | 1000Genomes | |
| tmp_5_17011692_G_A | 553 | D>N | No | 1000Genomes | |
| ENSVATH07302798 | 570 | Y>H | No | 1000Genomes | |
| tmp_5_17012565_C_A | 631 | S>* | No | 1000Genomes | |
| ENSVATH00696805 | 631 | S>T | No | 1000Genomes | |
| ENSVATH12380314 | 634 | T>I | No | 1000Genomes | |
| tmp_5_17012580_C_T | 636 | P>L | No | 1000Genomes | |
| tmp_5_17012609_G_T | 646 | A>S | No | 1000Genomes | |
| tmp_5_17012694_T_A | 647 | D>E | No | 1000Genomes | |
| ENSVATH12380325 | 652 | M>L | No | 1000Genomes | |
| ENSVATH12380325 | 652 | M>V | No | 1000Genomes | |
| ENSVATH12380328 | 672 | R>H | No | 1000Genomes | |
| ENSVATH03322344 | 677 | A>V | No | 1000Genomes | |
| ENSVATH00696806 | 679 | Q>L | No | 1000Genomes | |
| ENSVATH14568695 | 680 | V>A | No | 1000Genomes | |
| tmp_5_17013020_G_T | 690 | R>L | No | 1000Genomes | |
| ENSVATH07302813 | 712 | R>C | No | 1000Genomes | |
| tmp_5_17013089_C_G | 713 | S>C | No | 1000Genomes | |
| ENSVATH03322345 | 727 | A>T | No | 1000Genomes | |
| ENSVATH07302814 | 734 | D>Y | No | 1000Genomes | |
| ENSVATH07302821 | 739 | D>G | No | 1000Genomes | |
| ENSVATH12380330 | 754 | P>L | No | 1000Genomes | |
| tmp_5_17013400_C_G | 760 | T>R | No | 1000Genomes | |
| tmp_5_17013427_C_T | 769 | T>I | No | 1000Genomes | |
| tmp_5_17013434_A_T | 771 | Q>H | No | 1000Genomes | |
| tmp_5_17013573_T_G | 776 | I>R | No | 1000Genomes | |
| ENSVATH07302827 | 811 | G>A | No | 1000Genomes | |
| ENSVATH07302829 | 824 | P>L | No | 1000Genomes | |
| ENSVATH00696809 | 825 | P>S | No | 1000Genomes | |
| tmp_5_17014044_G_A | 850 | R>K | No | 1000Genomes | |
| ENSVATH07302832 | 862 | Y>C | No | 1000Genomes | |
| ENSVATH00696811 | 863 | M>T | No | 1000Genomes | |
| tmp_5_17014099_A_C | 868 | E>D | No | 1000Genomes | |
| ENSVATH07302834 | 896 | W>* | No | 1000Genomes | |
| ENSVATH07302833 | 896 | W>L | No | 1000Genomes | |
| tmp_5_17014194_C_G,T | 900 | P>L | No | 1000Genomes | |
| tmp_5_17014194_C_G,T | 900 | P>R | No | 1000Genomes | |
| ENSVATH12380385 | 906 | P>L | No | 1000Genomes | |
| ENSVATH03322351 | 910 | N>S | No | 1000Genomes | |
| ENSVATH07302835 | 917 | A>S | No | 1000Genomes | |
| ENSVATH00696812 | 917 | A>V | No | 1000Genomes | |
| ENSVATH12380386 | 935 | S>N | No | 1000Genomes | |
| ENSVATH07302836 | 951 | Q>R | No | 1000Genomes | |
| ENSVATH12380387 | 955 | T>P | No | 1000Genomes | |
| ENSVATH07302837 | 956 | R>Q | No | 1000Genomes | |
| tmp_5_17014381_C_A | 962 | N>K | No | 1000Genomes | |
| ENSVATH07302838 | 970 | T>S | No | 1000Genomes | |
| tmp_5_17014412_C_G | 973 | Q>E | No | 1000Genomes | |
| tmp_5_17014448_G_A | 985 | A>T | No | 1000Genomes | |
| ENSVATH14568699 | 994 | E>D | No | 1000Genomes | |
| ENSVATH12380390 | 994 | E>Q | No | 1000Genomes | |
| tmp_5_17014509_A_G | 1005 | Q>R | No | 1000Genomes | |
| ENSVATH00696813 | 1007 | A>G | No | 1000Genomes |
No associated diseases with Q9FQ02
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 5'-3' exoribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| zinc ion binding | Binding to a zinc ion (Zn). |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| miRNA catabolic process | The chemical reactions and pathways resulting in the breakdown of miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression. |
| mRNA processing | Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. |
| negative regulation of post-transcriptional gene silencing | Any process that decreases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism. |
| nuclear polyadenylation-dependent rRNA catabolic process | The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, including RNA fragments released as part of processing the primary transcript into multiple mature rRNA species, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA. |
| nuclear-transcribed mRNA catabolic process | The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells. |
| rRNA 5'-end processing | Any process involved in forming the mature 5' end of an rRNA molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGVPSFYRWL | IQRYPLTIQE | VIEEEPLEVN | GGGVTIPIDS | SKPNPNGYEY | DNLYLDMNGI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IHPCFHPEDK | PSPTTFTEVF | QCMFDYIDRL | FVMVRPRKLL | FMAIDGVAPR | AKMNQQRARR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FRAAKDAAEA | AAEEEQLREE | FEREGKKLPP | KVDSQVFDSN | VITPGTEFMA | TLSFALRYYI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HVRLNSDPGW | KNIKVILSDA | NVPGEGEHKI | MSYIRCNKNH | PGYNPNTHHC | LYGLDADLIM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LSLATHEIHF | SILREVVFFP | GEEGKCFLCG | QEGHRAADCE | GKIKRKTGEM | LDNTEADVVV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KKPYEFVNIW | ILREYLEHDM | QIPGAKKNLD | RLIDDFIFIC | FFVGNDFLPH | MPTLEIREGA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IELLMSVYKN | KFRSAKKYLT | DSSKLNLRNV | ERFIKAVGMY | ENQIFQKRAQ | VQQRQSERFR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RDKARDKARD | NARDNAQASR | QFSGKLVQLD | SLDEVSDSLH | SSPSRKYLRL | SLDDNIGVAN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VETENSLKAE | ELDNEEDLKF | KLKKLLRDKG | DGFRSGNGEQ | DKVKLNKVGW | RERYYEEKFA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AKSVEEMEQI | RRDVVLKYTE | GLCWIMHYYY | HGVCSWNWFY | PYHYAPFASD | LKGLEKLDIK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| FELGSPFKPF | NQLLAVLPSA | SAHALPECYR | SLMTNPDSPI | ADFYPADFEI | DMNGKRYSWQ |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GISKLPFVEE | KRLLEAAAQV | EKSLTNEEIR | RNSALFDMLF | VVASHPLGEL | IRSLNSRTNN |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LSNEERATII | EKIDPGLSDG | MNGYIASCGG | DSQPSCFCST | VEGMEDVLTN | QVICAIYKLP |
| 790 | 800 | 810 | 820 | 830 | 840 |
| EDIRGSEITH | QIPRLAIPKK | TISLVDLKSG | GLLWHEDGDK | RRAPPKVIKI | KRYNPEGSIS |
| 850 | 860 | 870 | 880 | 890 | 900 |
| GGRLGKASHR | LVLQTINAQP | DYMNINSEPA | LCPNTVFQNE | RVPKKIPTFK | DNGIQWISPP |
| 910 | 920 | 930 | 940 | 950 | 960 |
| PSQITPKKMN | SPQRQKAWKK | DETPQSREKS | KKLKSSLKVN | PLKMKKTKSP | QREFTREKKK |
| 970 | 980 | 990 | 1000 | 1010 | |
| ENITPQRKLT | KAQRQVKHIR | MMEEAKMIKQ | RKKEKYLRKK | AKYAQGAPPK | TA |