Q9FNG3
Gene name |
RICE2 |
Protein name |
Protein RISC-INTERACTING CLEARING 3'-5' EXORIBONUCLEASE 2 |
Names |
DnaQ-like 3'-5' exonuclease domain-containing protein, AtDECP |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G06450 |
EC number |
3.1.13.1: Exoribonucleases producing 5'-phosphomonoesters |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for Q9FNG3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1VK0 | X-ray | 210 A | A/B/C/D/E/F | 2-206 | PDB |
| 2Q3S | X-ray | 210 A | A/B/C/D/E/F | 2-206 | PDB |
| AF-Q9FNG3-F1 | Predicted | AlphaFoldDB |
17 variants for Q9FNG3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_1968470_G_A | 7 | P>L | No | 1000Genomes | |
| ENSVATH10610423 | 14 | G>A | No | 1000Genomes | |
| ENSVATH06931368 | 26 | S>L | No | 1000Genomes | |
| tmp_5_1968329_T_A | 54 | Y>F | No | 1000Genomes | |
| tmp_5_1968321_C_A | 57 | V>L | No | 1000Genomes | |
| tmp_5_1968314_A_C | 59 | F>C | No | 1000Genomes | |
| ENSVATH06931364 | 61 | E>A | No | 1000Genomes | |
| ENSVATH10610421 | 79 | S>N | No | 1000Genomes | |
| tmp_5_1968201_G_T | 97 | L>I | No | 1000Genomes | |
| ENSVATH13941409 | 99 | D>V | No | 1000Genomes | |
| ENSVATH06931362 | 101 | Y>F | No | 1000Genomes | |
| tmp_5_1968181_G_T | 103 | F>L | No | 1000Genomes | |
| ENSVATH06931361 | 112 | V>I | No | 1000Genomes | |
| ENSVATH06931360 | 121 | D>N | No | 1000Genomes | |
| ENSVATH00608976 | 124 | R>I | No | 1000Genomes | |
| tmp_5_1967963_T_C | 176 | K>R | No | 1000Genomes | |
| ENSVATH06931352 | 197 | V>I | No | 1000Genomes |
No associated diseases with Q9FNG3
No regional properties for Q9FNG3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9FNG3 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.13.1 | Exoribonucleases producing 5'-phosphomonoesters |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plant-type vacuole | A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| 3'-5' exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. |
| exoribonuclease II activity | Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction. |
| nucleic acid binding | Binding to a nucleic acid. |
| protein self-association | Binding to a domain within the same polypeptide. |
| RISC complex binding | Binding to a RISC complex. |
| single-stranded DNA 3'-5' exodeoxyribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| gene silencing by RNA | A process in which an RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation. |
| positive regulation of miRNA metabolic process | Any process that activates or increases the frequency, rate or extent of miRNA metabolic process. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASFDGPKFK | MTDGSYVQTK | TIDVGSSTDI | SPYLSLIRED | SILNGNRAVI | FDVYWDVGFP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ETETKTKTSG | WSLSSVKLST | RNLCLFLRLP | KPFHDNLKDL | YRFFASKFVT | FVGVQIEEDL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DLLRENHGLV | IRNAINVGKL | AAEARGTLVL | EFLGTRELAH | RVLWSDLGQL | DSIEAKWEKA |
| 190 | 200 | ||||
| GPEEQLEAAA | IEGWLIVNVW | DQLSDE |