Q9EZJ8

PR
Gene name
sigA
Protein name
RNA polymerase sigma factor SigA
Names
Species
Homo sapiens (Human)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

129-201 (Flexible loop) EV

Target domain

202-271 (σ2 domain)

Relief mechanism

Ligand binding

Assay

Structural analysis

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

19 structures for Q9EZJ8

Entry ID Method Resolution Chain Position Source
1KU2 X-ray 290 A A/B 92-332 PDB
1KU3 X-ray 180 A A 366-438 PDB
1KU7 X-ray 240 A A/D 366-438 PDB
1L9U X-ray 400 A H/Q 92-438 PDB
1L9Z X-ray 650 A H 1-438 PDB
1RIO X-ray 230 A H 366-438 PDB
3LES X-ray 277 A A/B 93-271 PDB
3LEV X-ray 250 A A 93-271 PDB
3N97 X-ray 325 A A/D 366-438 PDB
3UGO X-ray 210 A A 92-332 PDB
3UGP X-ray 270 A A 92-332 PDB
4KI2 X-ray 361 A A/B 92-332 PDB
4XLN X-ray 400 A F/L 92-438 PDB
4XLP X-ray 400 A F/L 92-438 PDB
4XLQ X-ray 460 A F/L 92-438 PDB
4XLR X-ray 430 A F/L 92-438 PDB
4XLS X-ray 401 A F/L 92-438 PDB
5TJG X-ray 260 A F 92-438 PDB
AF-Q9EZJ8-F1 Predicted AlphaFoldDB

No variants for Q9EZJ8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9EZJ8

No associated diseases with Q9EZJ8

No regional properties for Q9EZJ8

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9EZJ8

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Enriched in transcriptionally active regions of chromatin in neurons
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
sigma factor activity Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins.

1 GO annotations of biological process

Name Definition
DNA-templated transcription, initiation The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDRPDEGPPA KTRRLSSSES PQRDPPPPPP PPPLLRLPLP PPQQRPRLQE ETEAAQVLAD
70 80 90 100 110 120
MRGVGLGPAL PPPPPYVILE EGGIRAYFTL GAECPGWDST IESGYGEAPP PTESLEALPT
130 140 150 160 170 180
PEASGGSLEI DFQVVQSSSF GGEGALETCS AVGWAPQRLV DPKSKEEAII IVEDEDEDER
190 200 210 220 230 240
ESMRSSRRRR RRRRRKQRKV KRESRERNAE RMESILQALE DIQLDLEAVN IKAGKAFLRL
250 260 270 280 290 300
KRKFIQMRRP FLERRDLIIQ HIPGFWVKAF LNHPRISILI NRRDEDIFRY LTNLQVQDLR
310 320 330 340 350 360
HISMGYKMKL YFQTNPYFTN MVIVKEFQRN RSGRLVSHST PIRWHRGQEP QARRHGNQDA
370 380 390 400 410 420
SHSFFSWFSN HSLPEADRIA EIIKNDLWVN PLRYYLRERG SRIKRKKQEM KKRKTRGRCE
430 440 450 460 470 480
VVIMEDAPDY YAVEDIFSEI SDIDETIHDI KISDFMETTD YFETTDNEIT DINENICDSE
490 500 510 520 530 540
NPDHNEVPNN ETTDNNESAD DHETTDNNES ADDNNENPED NNKNTDDNEE NPNNNENTYG
550 560 570 580 590 600
NNFFKGGFWG SHGNNQDSSD SDNEADEASD DEDNDGNEGD NEGSDDDGNE GDNEGSDDDD
610 620 630 640 650 660
RDIEYYEKVI EDFDKDQADY EDVIEIISDE SVEEEGIEEG IQQDEDIYEE GNYEEEGSED
670 680 690
VWEEGEDSDD SDLEDVLQVP NGWANPGKRG KTG