Q9EYW9
Gene name |
gadB (lmo2363) |
Protein name |
Glutamate decarboxylase beta |
Names |
GAD-beta |
Species |
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) |
KEGG Pathway |
lmo:lmo2363 |
EC number |
4.1.1.15: Carboxy-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9EYW9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9EYW9-F1 | Predicted | AlphaFoldDB |
5 variants for Q9EYW9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| 92 | A>P | strain: LO28 [UniProt] | No | ||
| 124 | E>D | strain: LO28 [UniProt] | No | ||
| 261 | F>L | strain: EGD5 [UniProt] | No | ||
| 375 | C>R | strain: EGD5 [UniProt] | No | ||
| 380 | D>TT | strain: LO28 [UniProt] | No |
No associated diseases with Q9EYW9
5 regional properties for Q9EYW9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | GHMP kinase, ATP-binding, conserved site | 130 - 141 | IPR006203 |
| domain | GHMP kinase N-terminal domain | 124 - 190 | IPR006204 |
| domain | GHMP kinase, C-terminal domain | 294 - 375 | IPR013750 |
| domain | Galactokinase, N-terminal domain | 16 - 65 | IPR019539 |
| conserved_site | Galactokinase, conserved site | 35 - 46 | IPR019741 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.1.1.15 | Carboxy-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| glutamate decarboxylase activity | Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2. |
| pyridoxal phosphate binding | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| glutamate catabolic process | The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLYSKENKES | YLEPVFGSSA | EDRDIPKYTL | GKEPLEPRIA | YRLVKDELLD | EGSARQNLAT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FCQTYMEDEA | TKLMSETLEK | NAIDKSEYPR | TAELENRCVN | IIADLWHAPK | DQKFMGTSTI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GSSEACMLGG | MAMKFAWRKR | AEKLGLDIYA | KKPNLVISSG | YQVCWEKFCV | YWDIDMRVVP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MDKEHMQLNT | DQVLDYVDEY | TIGVVGILGI | TYTGRYDDIY | ALNEKLEEYN | SKTDYKVYIH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VDAASGGFFT | PFVEPDIIWD | FRLKNVISIN | TSGHKYGLVY | PGIGWVLWKD | ESYLPEELIF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KVSYLGGEMP | TMQINFSRSA | SHIIGQYYNF | LRYGFEGYRT | IHQKTSDVAQ | YLAHAVEQTG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YFDIFNDGSH | LPIVCYKLKD | DANVNWTLYD | LADRLQMRGW | QVPAYPLPKS | LENIIIQRYV |
| 430 | 440 | 450 | 460 | ||
| CRADLGFNMA | EEFIQDFQAS | IQELNNAHIL | FHDTQQSGVH | GFTH |