Q9ESJ4
Gene name |
Nckipsd (Spin90, Wasbp) |
Protein name |
NCK-interacting protein with SH3 domain |
Names |
54 kDa VacA-interacting protein, VIP54, 90 kDa N-WASP-interacting protein, 90 kDa SH3 protein interacting with Nck, SH3 adapter protein SPIN90, WASP-interacting SH3-domain protein, WISH, Wiskott-Aldrich syndrome protein-binding protein, N-WASP-binding protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:80987 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9ESJ4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9ESJ4-F1 | Predicted | AlphaFoldDB |
16 variants for Q9ESJ4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3400095824 | 78 | A>V | No | EVA | |
| rs3389083978 | 118 | T>N | No | EVA | |
| rs3389076010 | 161 | Y>H | No | EVA | |
| rs3389063887 | 211 | A>T | No | EVA | |
| rs3389053257 | 220 | Y>* | No | EVA | |
| rs3389074213 | 268 | V>M | No | EVA | |
| rs3389074203 | 304 | I>T | No | EVA | |
| rs3389084515 | 375 | E>D | No | EVA | |
| rs3400095865 | 390 | Q>L | No | EVA | |
| rs3400738540 | 392 | S>C | No | EVA | |
| rs3399566656 | 441 | Q>H | No | EVA | |
| rs3400116145 | 442 | M>L | No | EVA | |
| rs3389063886 | 516 | E>D | No | EVA | |
| rs3389076013 | 565 | I>F | No | EVA | |
| rs3389020032 | 676 | Q>P | No | EVA | |
| rs3389075998 | 693 | Q>H | No | EVA |
No associated diseases with Q9ESJ4
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| COP9 signalosome | A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| Arp2/3 complex binding | Binding to an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). |
| SH3 domain binding | Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. |
| positive regulation of neuron projection development | Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MYRALYAFRS | AEPNAMAFAA | GETFLVLERS | STHWWLAARA | RSGETGYVPP | AYLHRLQGME |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QDVLQAIDRA | IEAVHNTAMR | DGGKYSLEQR | GVLQKLIHHR | KETLSRRGTS | ASSATVMTPS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TSDHHLDAAV | SRQPNGVCRT | GFERQHSLPS | SEHLGTDGAL | YQVPPQPRRA | APTTPPPPVK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RRDREALVIS | GSGGRTAIPS | GGSSVSSGSS | ASSTSMDTLY | TGSSPSELGP | SCSPTPPPVP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RRGAHTTVSQ | PQPSPSKAPS | PEPPTEEVAA | ETNSTPDDLE | AQDALSPETT | EEKAAAETVV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PRTIGAELME | LVRRNTGLSH | ELCRVAIGVV | VGHIQATVPA | SSPIMEQVLL | SLVEGKDLST |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ALPSGQVCHD | QQRLEVIFAD | LARRKDDAQQ | RSWALYEDED | VIRCYLEELL | HILTDADPEV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| CKKMCKRSDF | ESVLALVAYY | QMEHRASLRL | LLLKCFGAMC | SLDAAIISTL | VSSVLPVELA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RDMQTDTQDH | QKLCYSALVL | AMVFSMGEAV | PYAHYEHLGT | PFAQFLLSIV | EDGLPMDTTE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QLPDLCMNLL | LALNLHLTAP | EQNVIMAALS | RHTNVKIFSE | KLLLLLNRGD | DPVRIFRHEP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QPPHSVLKFL | QDVFSSSATA | AIFYHTDMMA | LIDITVRQIA | DLSPGDKLRM | EYLSLMHAVV |
| 670 | 680 | 690 | 700 | 710 | |
| RSTPYLQHRH | RLSDLQATLR | RILTEEEASP | QCQMDRMIVQ | EMYKEFPDLG | EVPS |