Q9ES82
Gene name |
Popdc2 (Pop2) |
Protein name |
Popeye domain-containing protein 2 |
Names |
Popeye protein 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:64082 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9ES82
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9ES82-F1 | Predicted | AlphaFoldDB |
20 variants for Q9ES82
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389432516 | 27 | G>E | No | EVA | |
| rs3389331950 | 41 | F>Y | No | EVA | |
| rs3389410694 | 65 | V>E | No | EVA | |
| rs3389417026 | 75 | L>I | No | EVA | |
| rs3389432480 | 85 | T>S | No | EVA | |
| rs3406921048 | 121 | V>G | No | EVA | |
| rs3412921044 | 169 | Q>H | No | EVA | |
| rs215856394 | 193 | P>A | No | EVA | |
| rs3406276375 | 198 | T>S | No | EVA | |
| rs3389423699 | 203 | L>P | No | EVA | |
| rs3389413931 | 214 | W>R | No | EVA | |
| rs3389433136 | 224 | N>Y | No | EVA | |
| rs3389425846 | 251 | K>R | No | EVA | |
| rs3389414357 | 259 | R>H | No | EVA | |
| rs3389418280 | 267 | L>I | No | EVA | |
| rs3389425820 | 285 | D>V | No | EVA | |
| rs3389396802 | 295 | S>F | No | EVA | |
| rs264373584 | 312 | A>T | No | EVA | |
| rs3389332006 | 322 | P>S | No | EVA | |
| rs243073944 | 338 | N>T | No | EVA |
No associated diseases with Q9ES82
No regional properties for Q9ES82
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9ES82 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| sarcolemma | The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| cAMP binding | Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| heart development | The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
| regulation of heart rate | Any process that modulates the frequency or rate of heart contraction. |
| regulation of membrane potential | Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. |
| sinoatrial node cell development | The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node. |
| skeletal muscle tissue development | The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers. |
| striated muscle cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9HBU9 | POPDC2 | Popeye domain-containing protein 2 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSANGSSVAQ | LLWQPPVCRS | WKPDVEGAVY | HLANCFLLMG | FMAGSGVYGC | FYLFGILGPG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YLCCVLWGWF | DACGLDIVLW | NVLLTVACLL | QLAQLVYRVR | VNTLPEEFNL | LYRTLCLPLQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VPLQVYKEIV | HCCHEQVLTL | ATEQTYAVEG | ETPINRLSLL | LSGRVRVSQD | GQFLHYIFPY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QFMDSPEWES | LHPSEEGTFQ | VTLTAETECS | YISWPRKNLY | LLLNRERYIS | RLFSALLGYD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ISEKLYTLND | KLFAKFGLRF | DIRLPSLYHV | LSPSASDGEP | ESEKDDEEAL | EAAVSPAQAR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PICIVPTPPC | SAPPATTNFP | VPLPRARMPR | MPRPDSGNLA | SRRPLQNSSQ | VMSRSQAPLA |
| PIHTPEL |