Q9EQZ7

PR
Gene name
Rims2 (Rab3ip2, Rim2)
Protein name
Regulating synaptic membrane exocytosis protein 2
Names
Rab-3-interacting molecule 2, RIM 2, Rab-3-interacting protein 2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:116838
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

437-507 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9EQZ7

Entry ID Method Resolution Chain Position Source
AF-Q9EQZ7-F1 Predicted AlphaFoldDB

44 variants for Q9EQZ7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389331029 92 P>L No EVA
rs1134127234 157 A>V No EVA
rs3389364879 291 E>V No EVA
rs3412920676 304 G>D No EVA
rs46658433 322 P>S No EVA
rs3389357302 334 R>M No EVA
rs3389364856 387 Q>E No EVA
rs3389364906 394 R>C No EVA
rs3389279121 395 I>T No EVA
rs3389355761 398 E>V No EVA
rs3405981016 432 S>L No EVA
rs3389353895 443 A>T No EVA
rs3389330977 445 E>D No EVA
rs3389357305 454 R>K No EVA
rs3389349566 468 T>A No EVA
rs3389364839 526 D>Y No EVA
rs3406047348 535 P>S No EVA
rs3389320986 569 D>E No EVA
rs3389355751 668 R>H No EVA
rs3389353868 695 G>* No EVA
rs3406047364 718 T>S No EVA
rs234606580 769 P>L No EVA
rs214652826 774 S>G No EVA
rs3406048162 777 A>T No EVA
rs3389320992 795 S>P No EVA
rs3389349501 795 S>Y No EVA
rs3389353847 941 T>I No EVA
rs3389360837 1006 S>T No EVA
rs3410819000 1044 P>H No EVA
rs3389338895 1044 P>T No EVA
rs253205369 1053 H>L No EVA
rs3389353576 1246 N>D No EVA
rs3389357387 1253 T>N No EVA
rs3389373234 1264 K>N No EVA
rs3389364868 1318 W>L No EVA
rs3389340359 1331 S>R No EVA
rs3389353862 1359 D>E No EVA
rs3389360667 1432 K>M No EVA
rs3389355781 1433 V>M No EVA
rs3389331027 1435 R>* No EVA
rs48782882 1455 R>K No EVA
rs3389330956 1459 I>N No EVA
rs3389353812 1490 V>M No EVA
rs3389279059 1495 K>E No EVA

No associated diseases with Q9EQZ7

7 regional properties for Q9EQZ7

Type Name Position InterPro Accession
domain C2 domain 814 - 939 IPR000008-1
domain C2 domain 1376 - 1496 IPR000008-2
domain PDZ domain 677 - 765 IPR001478
domain Rab-binding domain 26 - 194 IPR010911
domain Zinc finger, FYVE-related 126 - 182 IPR017455
domain FYVE-type zinc finger 79 - 193 IPR041282
domain PDZ domain 6 706 - 763 IPR041489

Functions

Description
EC Number
Subcellular Localization
  • Synapse, synaptosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

11 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
cytoskeleton of presynaptic active zone The specialized cytoskeletal matrix of the presynaptic active zone. It has specialized functions in organizing synaptic events such as immobilisation or translocation of synaptic vesicles, and assembling active zone components. It is believed to form a molecular scaffold that organizes neurotransmitter release sites.
GABA-ergic synapse A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
glutamatergic synapse A synapse that uses glutamate as a neurotransmitter.
inhibitory synapse A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
photoreceptor ribbon synapse A ribbon synapse between a retinal photoreceptor cell (rod or cone) and a retinal bipolar cell. These contain a plate-like synaptic ribbon.
presynaptic active zone cytoplasmic component A specialized region below the presynaptic membrane, characterized by electron-dense material, a specialized cytoskeletal matrix and accumulated (associated) synaptic vesicles.
presynaptic membrane A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

6 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
protein domain specific binding Binding to a specific domain of a protein.
protein-containing complex binding Binding to a macromolecular complex.
small GTPase binding Binding to a small monomeric GTPase.
structural constituent of presynaptic active zone The action of a molecule that contributes to the structural integrity of a presynaptic active zone.
transmembrane transporter binding Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

18 GO annotations of biological process

Name Definition
adenylate cyclase-modulating G protein-coupled receptor signaling pathway A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP).
calcium ion-regulated exocytosis of neurotransmitter The release of a neurotransmitter into the synaptic cleft by exocytosis of synaptic vesicles, where the release step is dependent on a rise in cytosolic calcium ion levels.
calcium-ion regulated exocytosis The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
insulin secretion The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects.
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
neurotransmitter secretion The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
positive regulation of dendrite extension Any process that activates or increases the frequency, rate or extent of dendrite extension.
positive regulation of excitatory postsynaptic potential Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of inhibitory postsynaptic potential Any process that activates or increases the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential.
positive regulation of synaptic transmission Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
regulation of exocytosis Any process that modulates the frequency, rate or extent of exocytosis.
regulation of membrane potential Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
regulation of synaptic plasticity A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
spontaneous neurotransmitter secretion Neurotransmitter secretion that occurs in the absence of the action of a secretagogue or a presynaptic action potential.
synaptic vesicle docking The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process.
synaptic vesicle priming A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSAPLGPRGR PAPTPAASQP PPQPEMPDLS HLTEEERKII LAVMDRQKKE EEKEQSVLKI
70 80 90 100 110 120
KEEHKAQPTQ WFPFSGITEL VNNVLQPQQK QPNEKEPQTK LHQQFEMYKE QVKKMGEESQ
130 140 150 160 170 180
QQQEQKGDAP TCGICHKTKF ADGCGHNCSY CQTKFCARCG GRVSLRSNKV MWVCNLCRKQ
190 200 210 220 230 240
QEILTKSGAW FYNSGSNTLQ QPDQKVPRGL RNEEAPQEKK AKLHEQPQFQ GAPGDLSVPA
250 260 270 280 290 300
VEKGRAHGLT RQDTIKNGSG VKHQIASDMP SDRKRSPSVS RDQNRRYEQS EEREDYSQYV
310 320 330 340 350 360
PSDGTMPRSP SDYADRRSQR EPQFYEEPGH LNYRDSNRRG HRHSKEYIVD DEDVESRDEY
370 380 390 400 410 420
ERQRREEEYQ ARYRSDPNLA RYPVKPQPYE EQMRIHAEVS RARHERRHSD VSLANAELED
430 440 450 460 470 480
SRISLLRMDR PSRQRSVSER RAAMENQRSY SMERTREAQG QSSYPQRTSN HSPPTPRRSP
490 500 510 520 530 540
IPLDRPDMRR ADSLRKQHHL DPSSAVRKTK REKMETMLRN DSLSSDQSES VRPPPPRPHK
550 560 570 580 590 600
SKKGGKMRQV SLSSSEEELA STPEYTSCDD VELESESVSE KGDSQKGKRK TSEQGVLSDS
610 620 630 640 650 660
NTRSERQKKR MYYGGHSLEE DLEWSEPQIK DSGVDTCSST TLNEEHSHSD KHPVTWQPSK
670 680 690 700 710 720
DGDRLIGRIL LNKRLKDGSV PRDSGAMLGL KVVGGKMTES GRLCAFITKV KKGSLADTVG
730 740 750 760 770 780
HLRPGDEVLE WNGRLLQGAT FEEVYNIILE SKPEPQVELV VSRPIGDIPR IPDSTHAQLE
790 800 810 820 830 840
SSSSSFESQK MDRPSISVTS PMSPGMLRDV PQFLSGQLSI KLWFDKVGHQ LIVTILGAKD
850 860 870 880 890 900
LPSREDGRPR NPYVKIYFLP DRSDKNKRRT KTVKKTLEPK WNQTFIYSPV HRREFRERML
910 920 930 940 950 960
EITLWDQARV REEESEFLGE ILIELETALL DDEPHWYKLQ THDVSSLPLP RPSPYLPRRQ
970 980 990 1000 1010 1020
LHGESPTRRL QRSKRISDSE VSDYDCEDGV GVVSDYRHNG RDLQSSTLSV PEQVMSSNHC
1030 1040 1050 1060 1070 1080
SPSGSPHRVD VIGRTRSWSP SAPPPQRNVE QGHRGTRATG HYNTISRMDR HRVMDDHYSS
1090 1100 1110 1120 1130 1140
DRDRSHPRTG SVQTSPSSTP GTGRRGRQLP QLPPKGTLER SAMDIEERNR QMKLNKYKQV
1150 1160 1170 1180 1190 1200
AGSDPRLEQD YHSKYRSGWD PHRGADTVST KSSDSDVSDV SAVSRTSSAS RFSSTSYMSV
1210 1220 1230 1240 1250 1260
QSERPRGNRK ISVFTSKMQN RQMGVSGKNL TKSTSISGDM CSLEKNDGSQ SDTAVGALGT
1270 1280 1290 1300 1310 1320
SGKKRRSSIG AKMVAIVGLS RKSRSASQLS QTEGGGKKLR STVQRSTETG LAVEMRNWMT
1330 1340 1350 1360 1370 1380
RQASRESTDG SMNSYSSEGN LIFPGVRLAS DSQFSDFLDG LGPAQLVGRQ TLATPAMGDI
1390 1400 1410 1420 1430 1440
QVGMMDKKGQ LEVEIIRARG LVVKPGSKTL PAPYVKVYLL DNGVCIAKKK TKVARKTLEP
1450 1460 1470 1480 1490 1500
LYQQLLSFEE SPQGRVLQII VWGDYGRMDH KSFMGVAQIL LDELELSNMV IGWFKLFPPS
1510 1520
SLVDPTLAPL TRRASQSSLE SSTGPSYSRS