Q9EPW0

PR
Gene name
Inpp4a
Protein name
Inositol polyphosphate-4-phosphatase type I A
Names
Inositol polyphosphate 4-phosphatase type I, Inositol polyphosphate 4-phosphatase-1, 4-Ptase-1, Type I inositol 3,4-bisphosphate 4-phosphatase
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:269180
EC number
3.1.3.66: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

453-612 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9EPW0

Entry ID Method Resolution Chain Position Source
AF-Q9EPW0-F1 Predicted AlphaFoldDB

No variants for Q9EPW0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9EPW0

No associated diseases with Q9EPW0

1 regional properties for Q9EPW0

Type Name Position InterPro Accession
domain C2 domain 26 - 153 IPR000008

Functions

Description
EC Number 3.1.3.66 Phosphoric monoester hydrolases
Subcellular Localization
  • Early endosome membrane
  • Recycling endosome membrane
  • Cell membrane
  • Nucleus
  • Cytoplasm
  • Postsynaptic density
  • Translocates to the plasma membrane upon EGF stimulation (By similarity)
  • Shuttles between the cytoplasm and the nucleus, depending on the cell cycle stage, with highest amounts detected in the nucleus during the G0/G1phase (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
early endosome membrane The lipid bilayer surrounding an early endosome.
nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynaptic density An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
recycling endosome membrane The lipid bilayer surrounding a recycling endosome.

4 GO annotations of molecular function

Name Definition
inositol-1,3,4-trisphosphate 4-phosphatase activity Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 1,3-bisphosphate + phosphate.
inositol-3,4-bisphosphate 4-phosphatase activity Catalysis of the reaction: 1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate.
phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.
phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.

1 GO annotations of biological process

Name Definition
polyphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a polyphosphate, the anion or salt of polyphosphoric acid.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96PE3 INPP4A Inositol polyphosphate-4-phosphatase type I A Homo sapiens (Human) PR
Q62784 Inpp4a Inositol polyphosphate-4-phosphatase type I A Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MTAREHSPRH GARARAMQRA STIDVAADMV GLSLAGNIQD PDEPILEFSL ACSELHTPSL
70 80 90 100 110 120
DRKPNSFVAV SVTTPPQAFW TKHAQTEIIE GTNNPIFLSS IAFFQDSLIN QMTQIKLSVY
130 140 150 160 170 180
DVKDRSQGTM YLLGSGTFVV KDLLQDRHHR LHLTLRSAES DRVGNITVIG WQMEEKSDQQ
190 200 210 220 230 240
PPVTRFLDTV NGRMVLPVDE SLTEALGIRS KYAFLRKDSL LKAVFGGAIC RMYRFPTTDG
250 260 270 280 290 300
NHLRILEQMA ESVLSLHVPR QFVKLLLEED AARVCELEEL GELSPCWESL RRQIVTQYQT
310 320 330 340 350 360
IILTYQENLT DLHQYKGPSF KASSLKADKK LEFVPTNLHI QRMRVQDDGG SDQNYDVVTI
370 380 390 400 410 420
GAPAAHCQGF KSGGLRKKLH KFEEAKKHSF EECCTSSSGQ SIIYIPQDIT RAKEIIAQIN
430 440 450 460 470 480
TLKTQVSYYA ERLSRAAKDR SATGLERTLA ILADKTRQLV TVCDCKLLAN SIHGLNAARP
490 500 510 520 530 540
DYIASKASPT STEEEQVMLR NDQDTLMARW AGRSSRSSLQ VDWHEEEWQK VWLNVDKSLE
550 560 570 580 590 600
CIIQRVDKLL QKDRLHGEGC EDAFPCSSTC SSKKDCSPPP EESSPGEWSE ALYPLLTTLT
610 620 630 640 650 660
DCVAMMSDKA KAAMVFLLMQ DSAPTIASYL SLQYRRDVVF CQTLTALICG FIIKLRNCLH
670 680 690 700 710 720
DGGFLRQLYT IGLLAQFESL LSTYGEELAM LEDMSLGIMD LRNVTFKVTQ ATSNASSDML
730 740 750 760 770 780
PVITGNRDGF NVRIPLPGPL VDSFPREIQS GMLLRVQPVL FNVGINEQQT LAERFGDTSL
790 800 810 820 830 840
QEGINGESLV RVNSYFEQFK EVLPEDCLPR SRSQTCLPEL LRFLGQNVHA RKNKNVDILW
850 860 870 880 890 900
QAAEVCRRLN GVRFTSCKSA KDRTAMSVTL EQCLILQHEH GMAPQVFTQA LECMRSEGCR
910 920 930
RENTMKNVGS RKYAFNSLQL KAFPKHYRPP EGTYGKVET