Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q9EPR4

Entry ID Method Resolution Chain Position Source
AF-Q9EPR4-F1 Predicted AlphaFoldDB

24 variants for Q9EPR4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388587911 25 E>V No EVA
rs3388589620 34 T>N No EVA
rs3392242150 84 P>T No EVA
rs3388596209 181 S>Y No EVA
rs3388591214 196 N>Y No EVA
rs3388594099 256 G>V No EVA
rs3392203005 295 Y>C No EVA
rs3391952099 299 K>R No EVA
rs3388589602 350 R>S No EVA
rs3388589612 354 L>I No EVA
rs3388587909 419 V>M No EVA
rs3388597976 428 G>D No EVA
rs3388592969 438 S>T No EVA
rs3388591208 476 L>P No EVA
rs27243399 507 I>V No EVA
rs3388591874 540 G>* No EVA
rs27243419 547 I>V No EVA
rs1132538667 572 G>D No EVA
rs1135044604 575 E>V No EVA
rs1132858465 576 E>D No EVA
rs3388591983 606 N>D No EVA
rs3388591974 610 K>Q No EVA
rs3388589667 622 T>I No EVA
rs3388594085 627 T>I No EVA

1 associated diseases with Q9EPR4

Without disease ID

No regional properties for Q9EPR4

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9EPR4

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
basal plasma membrane The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
L-ascorbate:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-ascorbate(out) + Na+(out) = L-ascorbate(in) + Na+(in).
L-ascorbic acid transmembrane transporter activity Enables the transfer of L-ascorbate from one side of a membrane to the other. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species.

6 GO annotations of biological process

Name Definition
cellular response to ethanol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
L-ascorbic acid metabolic process The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.
L-ascorbic acid transmembrane transport The process in which L-ascorbic acid is transported across a lipid bilayer, from one side of a membrane to the other. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species.
negative regulation of neuron death Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
positive regulation of dendrite extension Any process that activates or increases the frequency, rate or extent of dendrite extension.
response to oxidative stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UHI7 SLC23A1 Solute carrier family 23 member 1 Homo sapiens (Human) PR
Q9UGH3 SLC23A2 Solute carrier family 23 member 2 Homo sapiens (Human) PR
P93039 IDH2 Nucleobase-ascorbate transporter 4 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MMGIGKNTAS KSVEAGGSTE GKYEEEAKHS NFFTLPVVIN GGATSSGEQD NEDTELMAIY
70 80 90 100 110 120
TTENGIAEKS SLAETLDSTG SLDPQRSDMI YTIEDVPPWY LCIFLGLQHY LTCFSGTIAV
130 140 150 160 170 180
PFLLADAMCV GDDQWATSQL IGTIFFCVGI TTLLQTTFGC RLPLFQASAF AFLAPARAIL
190 200 210 220 230 240
SLDKWKCNTT EITVANGTAE LLEHIWHPRI QEIQGAIIMS SLIEVVIGLL GLPGALLRYI
250 260 270 280 290 300
GPLTITPTVA LIGLSGFQAA GERAGKHWGI AMLTIFLVLL FSQYARNVKF PLPIYKSKKG
310 320 330 340 350 360
WTAYKFQLFK MFPIILAILV SWLLCFIFTV TDVFPSNSTD YGYYARTDAR KGVLLVAPWF
370 380 390 400 410 420
KVPYPFQWGM PTVSAAGVIG MLSAVVASII ESIGDYYACA RLSCAPPPPI HAINRGIFVE
430 440 450 460 470 480
GLSCVLDGIF GTGNGSTSSS PNIGVLGITK VGSRRVIQYG AALMLGLGMV GKFSALFASL
490 500 510 520 530 540
PDPVLGALFC TLFGMITAVG LSNLQFIDLN SSRNLFVLGF SIFFGLVLPS YLRQNPLVTG
550 560 570 580 590 600
ITGIDQILNV LLTTAMFVGG CVAFILDNTI PGTPEERGIK KWKKGVSKGS KSLDGMESYN
610 620 630 640
LPFGMNIIKK YRCFSYLPIS PTFAGYTWKG FGKSENSRSS DKDSQATV