Q9EPR4
Gene name |
Slc23a2 |
Protein name |
Solute carrier family 23 member 2 |
Names |
Na(+)/L-ascorbic acid transporter 2, Sodium-dependent vitamin C transporter 2, SVCT-2, mSVCT2, Yolk sac permease-like molecule 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:54338 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9EPR4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9EPR4-F1 | Predicted | AlphaFoldDB |
24 variants for Q9EPR4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388587911 | 25 | E>V | No | EVA | |
| rs3388589620 | 34 | T>N | No | EVA | |
| rs3392242150 | 84 | P>T | No | EVA | |
| rs3388596209 | 181 | S>Y | No | EVA | |
| rs3388591214 | 196 | N>Y | No | EVA | |
| rs3388594099 | 256 | G>V | No | EVA | |
| rs3392203005 | 295 | Y>C | No | EVA | |
| rs3391952099 | 299 | K>R | No | EVA | |
| rs3388589602 | 350 | R>S | No | EVA | |
| rs3388589612 | 354 | L>I | No | EVA | |
| rs3388587909 | 419 | V>M | No | EVA | |
| rs3388597976 | 428 | G>D | No | EVA | |
| rs3388592969 | 438 | S>T | No | EVA | |
| rs3388591208 | 476 | L>P | No | EVA | |
| rs27243399 | 507 | I>V | No | EVA | |
| rs3388591874 | 540 | G>* | No | EVA | |
| rs27243419 | 547 | I>V | No | EVA | |
| rs1132538667 | 572 | G>D | No | EVA | |
| rs1135044604 | 575 | E>V | No | EVA | |
| rs1132858465 | 576 | E>D | No | EVA | |
| rs3388591983 | 606 | N>D | No | EVA | |
| rs3388591974 | 610 | K>Q | No | EVA | |
| rs3388589667 | 622 | T>I | No | EVA | |
| rs3388594085 | 627 | T>I | No | EVA |
1 associated diseases with Q9EPR4
Without disease ID
No regional properties for Q9EPR4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9EPR4 | |||
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| basal plasma membrane | The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| L-ascorbate:sodium symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-ascorbate(out) + Na+(out) = L-ascorbate(in) + Na+(in). |
| L-ascorbic acid transmembrane transporter activity | Enables the transfer of L-ascorbate from one side of a membrane to the other. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to ethanol | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. |
| L-ascorbic acid metabolic process | The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. |
| L-ascorbic acid transmembrane transport | The process in which L-ascorbic acid is transported across a lipid bilayer, from one side of a membrane to the other. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species. |
| negative regulation of neuron death | Any process that stops, prevents or reduces the frequency, rate or extent of neuron death. |
| positive regulation of dendrite extension | Any process that activates or increases the frequency, rate or extent of dendrite extension. |
| response to oxidative stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMGIGKNTAS | KSVEAGGSTE | GKYEEEAKHS | NFFTLPVVIN | GGATSSGEQD | NEDTELMAIY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TTENGIAEKS | SLAETLDSTG | SLDPQRSDMI | YTIEDVPPWY | LCIFLGLQHY | LTCFSGTIAV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PFLLADAMCV | GDDQWATSQL | IGTIFFCVGI | TTLLQTTFGC | RLPLFQASAF | AFLAPARAIL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SLDKWKCNTT | EITVANGTAE | LLEHIWHPRI | QEIQGAIIMS | SLIEVVIGLL | GLPGALLRYI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GPLTITPTVA | LIGLSGFQAA | GERAGKHWGI | AMLTIFLVLL | FSQYARNVKF | PLPIYKSKKG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| WTAYKFQLFK | MFPIILAILV | SWLLCFIFTV | TDVFPSNSTD | YGYYARTDAR | KGVLLVAPWF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KVPYPFQWGM | PTVSAAGVIG | MLSAVVASII | ESIGDYYACA | RLSCAPPPPI | HAINRGIFVE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GLSCVLDGIF | GTGNGSTSSS | PNIGVLGITK | VGSRRVIQYG | AALMLGLGMV | GKFSALFASL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PDPVLGALFC | TLFGMITAVG | LSNLQFIDLN | SSRNLFVLGF | SIFFGLVLPS | YLRQNPLVTG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ITGIDQILNV | LLTTAMFVGG | CVAFILDNTI | PGTPEERGIK | KWKKGVSKGS | KSLDGMESYN |
| 610 | 620 | 630 | 640 | ||
| LPFGMNIIKK | YRCFSYLPIS | PTFAGYTWKG | FGKSENSRSS | DKDSQATV |