Q9EPI1

PR
Gene name
Xylt1
Protein name
Xylosyltransferase 1
Names
Peptide O-xylosyltransferase 1, Xylosyltransferase I
Species
Rattus norvegicus (Rat)
KEGG Pathway
EC number
2.4.2.26: Pentosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-156 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9EPI1

Entry ID Method Resolution Chain Position Source
AF-Q9EPI1-F1 Predicted AlphaFoldDB

No variants for Q9EPI1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9EPI1

No associated diseases with Q9EPI1

1 regional properties for Q9EPI1

Type Name Position InterPro Accession
domain Xylosyltransferase, C-terminal 478 - 658 IPR024448

Functions

Description
EC Number 2.4.2.26 Pentosyltransferases
Subcellular Localization
  • Golgi apparatus membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi cis cisterna The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
protein xylosyltransferase activity Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate.

10 GO annotations of biological process

Name Definition
cellular response to heat Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
chondroitin sulfate biosynthetic process The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.
chondroitin sulfate proteoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.
embryonic skeletal system development The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure.
glycosaminoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars.
heparan sulfate proteoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
negative regulation of axon regeneration Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration.
ossification involved in bone maturation The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state.
proteoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.
response to interleukin-1 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q7KVA1 oxt Xylosyltransferase oxt Drosophila melanogaster (Fruit fly) PR
10 20 30 40 50 60
YFSHRPKEKV RTDSNNENSV PKDFENVDNS NFAPRTQKQK HQPELAKKPL SRQKERLQRK
70 80 90 100 110 120
LGAQDKGQGQ SVLGKGPKEV LPPREKAPGN SSQGKDLSRH SHSRKSGGGG SPETKSDQVP
130 140 150 160 170 180
KCDISGKEAI SALTRAKSKH CRQEIAETYC RHKLGLLMPE KVARFCPLEG KANKNVQWDE
190 200 210 220 230 240
DAVEYMPPNP VRIAFVLVVH GRASRQLQRM FKAIYHKDHF YYIHVDKRSN YLHRQVLQFS
250 260 270 280 290 300
RQYDNVRVTS WRMATIWGGA SLLSTYLQSM RDLLEMTDWP WDFFINLSAA DYPIRTNDQL
310 320 330 340 350 360
VAFLSRYRDM NFLKSHGRDN ARFIRKQDLD RLFLECDTHM WRLGDRRIPE GIAVDGGSDW
370 380 390 400 410 420
FLLNRKFVEY VAFSTDDLVT KMKQFYSYTL LPAESFFHTV LENSPHCDTM VDNNLRITNW
430 440 450 460 470 480
NRKLGCKCQY KHIVDWCGCS PNDFKPQDFH RFQQTARPTF FARKFEAIVN QEIIGQLDSY
490 500 510 520 530 540
LYGNYPAGTP GLRSYWENVY DEPDGIQSLS DVALTMYHSF IRLGLRRAES SLHTDGENSC
550 560 570 580 590 600
RYYPMGHPAS VHLYFLADRF QGFLIKHHVT NLAVSKLETL ETWMMPKKVF KVASPPSDFG
610 620 630 640 650 660
RLQFSEVGTD WDAKERLFRN FGGLLGPMDE PVGMQKWGKG PNVTVTVIWV DPVNVIAATY
670 680 690 700 710 720
DILIESTAEF THYKPPLNLP LRPGVWTVKI LHHWVPVAET KFLVAPLTFS NKQPIKPEEA
730 740 750 760 770 780
LKLHNGPPRS AYMEQSFQSL NPVLSLHINP AQVEQARKNA AFTGTALEAW LVGGTWTAMD
790 800 810 820
VCATGPTACP VMQTCSQTAW SSFSPDPKSE LGAVKPDGRL R