Q9EPA0
Gene name |
Drp2 |
Protein name |
Dystrophin-related protein 2 |
Names |
DRP-2 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:66027 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9EPA0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9EPA0-F1 | Predicted | AlphaFoldDB |
1 variants for Q9EPA0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3323249643 | 255 | A>S | No | EVA |
No associated diseases with Q9EPA0
6 regional properties for Q9EPA0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Zinc finger, ZZ-type | 604 - 661 | IPR000433 |
| domain | WW domain | 352 - 385 | IPR001202 |
| repeat | Spectrin repeat | 232 - 337 | IPR002017 |
| domain | EF-hand domain, type 1 | 386 - 504 | IPR015153 |
| domain | EF-hand domain, type 2 | 509 - 598 | IPR015154 |
| repeat | Spectrin/alpha-actinin | 105 - 339 | IPR018159 |
Functions
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| perikaryon | The portion of the cell soma (neuronal cell body) that excludes the nucleus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynaptic density | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| zinc ion binding | Binding to a zinc ion (Zn). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| central nervous system development | The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. |
| synapse organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). |
| synaptic signaling | Cell-cell signaling to, from or within a synapse. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQPLVMQGCP | YTLPRCHEWH | AADRFHHSSS | LRNTCPQPQV | RAAVTIPAPP | WDGAGDPCLS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PKLLNGSVGA | VGPLEPSAMN | LCWNEIKKKS | HNLRARLEAF | SDHSGKLQLP | LQEIIDWLSQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KDEELSAQLP | LQGDVALVQQ | EKETHAAFME | EVKSKGPYIY | SVLESAQAFL | SQHPFEELEE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SHSESKDTSP | RQRIQNLSRF | VWKQATVASE | LWEKLTARCV | DQHRHIEHTL | EHLLEIQGAM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EELSSTLTQA | EGVRATWEPI | GDLFIDSLPE | HIQAIKLFKE | EFSPVKDGVK | LVNDLAHQLA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ISDVHLSMEN | SRALEQINVR | WKQLQVSVAE | RLKQLQDAHR | DFGPGSQHFL | STSVQVPWER |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AISPNKVPYY | INHQAQTTCW | DHPKMTELYQ | TLADLNNIKF | SAYRTAMKLR | RVQKALRLDL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VTLTTALEIF | NEHDLQASEH | VMDVVEVIHC | LTALYERLEE | ERGILVNVPL | CVDMSLNWLL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NVFDSGRSGK | MRALSFKTGI | ACLCGTEVKE | KLQYLFSQVA | NSGSQCDQRH | LGALLHEAIQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VPRQLGEVAA | FGGSNVEPSV | RSCFRFSTGK | PVIEASQFLE | WVNLEPQSMV | WLAVLHRVTV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| AEQVKHQTKC | SICRQCPIKG | FRYRSLKQFN | VDICQTCFLT | GKASKGNKLH | YPIMEYYTPT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TSSENMRDFA | TTLKNKFRSK | QYFSKHPQRG | YLPVQSVLES | DCSETPASSP | MLPHADTHSR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| IEHFASRLAE | MESQNCSFFN | DSLSPDDSID | EDQYLLRHSS | PITDREPAFG | QQAPCSMATE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SKGELEKILA | HLEDENRILQ | GELRRLKWQH | EEAVEAPTLA | EGSAEATPDH | RNEELLAEAR |
| 850 | 860 | 870 | 880 | 890 | 900 |
| ILRQHKSRLE | TRMQILEDHN | KQLESQLQRL | RELLLQPPTE | SDGNGSAGSS | LASSPRQSEG |
| 910 | 920 | 930 | 940 | 950 | |
| SHPREKGQTT | PDTEAADDVG | SKSQDVSLCL | EDIMEKLRHA | FPSVRSSDVT | ANTLLAS |