Q9DCJ9
Gene name |
Npl |
Protein name |
N-acetylneuraminate lyase |
Names |
NALase, N-acetylneuraminate pyruvate-lyase, N-acetylneuraminic acid aldolase, Sialate lyase, Sialate-pyruvate lyase, Sialic acid aldolase, Sialic acid lyase |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:74091 |
EC number |
4.1.3.3: Oxo-acid-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9DCJ9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9DCJ9-F1 | Predicted | AlphaFoldDB |
21 variants for Q9DCJ9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3390780575 | 27 | F>I | No | EVA | |
| rs3390808359 | 29 | V>D | No | EVA | |
| rs3390808333 | 33 | Y>* | No | EVA | |
| rs3390728697 | 33 | Y>D | No | EVA | |
| rs3390820677 | 36 | Y>F | No | EVA | |
| rs261559067 | 90 | V>L | No | EVA | |
| rs3388507867 | 135 | A>T | No | EVA | |
| rs3388505670 | 149 | T>N | No | EVA | |
| rs214351582 | 191 | Q>H | No | EVA | |
| rs3388508492 | 226 | K>N | No | EVA | |
| rs3388505499 | 226 | K>R | No | EVA | |
| rs3390779911 | 245 | Y>D | No | EVA | |
| rs3388508438 | 267 | K>* | No | EVA | |
| rs3388508428 | 299 | K>M | No | EVA | |
| rs3390821101 | 310 | S>P | No | EVA | |
| rs3390815929 | 310 | S>R | No | EVA | |
| rs3390723744 | 310 | S>T | No | EVA | |
| rs3390779902 | 312 | K>N | No | EVA | |
| rs3390836338 | 312 | K>Q | No | EVA | |
| rs3390811526 | 313 | E>* | No | EVA | |
| rs245886319 | 318 | A>T | No | EVA |
No associated diseases with Q9DCJ9
No regional properties for Q9DCJ9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9DCJ9 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 4.1.3.3 | Oxo-acid-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| N-acetylneuraminate lyase activity | Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| carbohydrate metabolic process | The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. |
| N-acetylneuraminate catabolic process | The chemical reactions and pathways resulting in the breakdown of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAFPKKKLRG | LVAATITPMT | ENGEINFPVI | GQYVDYLVKE | QGVKNIFVNG | TTGEGLSLSV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SERRQVAEEW | VNQGRNKLDQ | VVIHVGALNV | KESQELAQHA | AEIGADGIAV | IAPFFFKSQN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KDALISFLRE | VAAAAPTLPF | YYYHMPSMTG | VKIRAEELLD | GIQDKIPTFQ | GLKFTDTDLL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DFGQCVDQNH | QRQFALLFGV | DEQLLSALVM | GATGAVGSTY | NYLGKKTNQM | LEAFEQKDLA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SALSYQFRIQ | RFINYVIKLG | FGVSQTKAIM | TLVSGIPMGP | PRLPLQKATQ | EFTAKAEAKL |
| 310 | |||||
| KSLDFLSSPS | VKEGKPLASA |