Q9DCJ5

PR
Gene name
Ndufa8
Protein name
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
Names
Complex I-19kD, CI-19kD, Complex I-PGIV, CI-PGIV, NADH-ubiquinone oxidoreductase 19 kDa subunit
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:68375
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

14 structures for Q9DCJ5

Entry ID Method Resolution Chain Position Source
6G2J EM 330 A X 1-172 PDB
6G72 EM 390 A X 1-172 PDB
6ZR2 EM 310 A X 1-172 PDB
6ZTQ EM 300 A X 1-172 PDB
7AK5 EM 317 A X 1-172 PDB
7AK6 EM 382 A X 1-172 PDB
7B93 EM 304 A X 1-172 PDB
7PSA EM 340 A X 1-172 PDB
8C2S EM 390 A X 1-172 PDB
8CA3 EM 320 A X 1-172 PDB
8CA5 EM 390 A X 1-172 PDB
8OLT EM 284 A X 1-172 PDB
8OM1 EM 239 A X 1-172 PDB
AF-Q9DCJ5-F1 Predicted AlphaFoldDB

7 variants for Q9DCJ5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388548887 7 L>P No EVA
rs3388546150 94 M>I No EVA
rs3388551453 105 A>P No EVA
rs3388548250 123 G>R No EVA
rs3388548273 147 R>M No EVA
rs3388546137 155 E>V No EVA
rs3391473505 161 A>T No EVA

No associated diseases with Q9DCJ5

1 regional properties for Q9DCJ5

Type Name Position InterPro Accession
domain CHCH 78 - 112 IPR010625

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Peripheral membrane protein
  • Mitochondrion intermembrane space
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial intermembrane space The region between the inner and outer lipid bilayers of the mitochondrial envelope.
mitochondrial respiratory chain complex I A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

1 GO annotations of molecular function

Name Definition
protein-containing complex binding Binding to a macromolecular complex.

4 GO annotations of biological process

Name Definition
aerobic respiration The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.
mitochondrial electron transport, NADH to ubiquinone The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation.
mitochondrial respiratory chain complex I assembly The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I.
proton motive force-driven mitochondrial ATP synthesis The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPGIVELPTL EELKVEEVKV SSAVLKAAAH HYGAQCDKTN KEFMLCRWEE KDPRRCLKEG
70 80 90 100 110 120
KLVNGCALNF FRQIKSHCAE PFTEYWTCLD YSNMQLFRHC RQQQAKFDQC VLDKLGWVRP
130 140 150 160 170
DLGQLSKVTK VKTDRPLPEN PYHSRARPEP NPVIEGDLKP AKHGTRFFFW TV