Q9DC48
Gene name |
Cdc40 (Prp17, Prpf17) |
Protein name |
Pre-mRNA-processing factor 17 |
Names |
Cell division cycle 40 homolog, PRP17 homolog |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:71713 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9DC48
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9DC48-F1 | Predicted | AlphaFoldDB |
31 variants for Q9DC48
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3400481102 | 8 | L>I | No | EVA | |
| rs3400978381 | 8 | L>R | No | EVA | |
| rs3401364339 | 17 | G>V | No | EVA | |
| rs3401138572 | 24 | S>R | No | EVA | |
| rs3401061022 | 113 | G>V | No | EVA | |
| rs3389105378 | 132 | F>L | No | EVA | |
| rs3389089613 | 152 | Y>C | No | EVA | |
| rs3389098175 | 175 | T>P | No | EVA | |
| rs3389098175 | 175 | T>S | No | EVA | |
| rs3389040988 | 184 | N>I | No | EVA | |
| rs3389092099 | 186 | A>T | No | EVA | |
| rs3389098011 | 196 | W>R | No | EVA | |
| rs3389041044 | 229 | Q>* | No | EVA | |
| rs3389070522 | 236 | E>K | No | EVA | |
| rs3389096156 | 250 | Q>H | No | EVA | |
| rs3389098198 | 259 | Q>* | No | EVA | |
| rs3389097966 | 262 | G>S | No | EVA | |
| rs1132903926 | 301 | G>V | No | EVA | |
| rs1132280812 | 304 | L>F | No | EVA | |
| rs1133632375 | 314 | K>N | No | EVA | |
| rs3389063544 | 353 | D>V | No | EVA | |
| rs3389089539 | 355 | Y>N | No | EVA | |
| rs3389083325 | 369 | R>G | No | EVA | |
| rs3389095921 | 373 | R>H | No | EVA | |
| rs3389075736 | 375 | V>A | No | EVA | |
| rs3389089606 | 408 | G>E | No | EVA | |
| rs3389096092 | 417 | H>L | No | EVA | |
| rs3389097953 | 496 | L>* | No | EVA | |
| rs3389083360 | 513 | Q>* | No | EVA | |
| rs3389095973 | 544 | S>G | No | EVA | |
| rs3389041025 | 561 | H>R | No | EVA |
No associated diseases with Q9DC48
6 regional properties for Q9DC48
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 277 - 318 | IPR001680-1 |
| repeat | WD40 repeat | 321 - 404 | IPR001680-2 |
| repeat | WD40 repeat | 407 - 446 | IPR001680-3 |
| repeat | WD40 repeat | 452 - 489 | IPR001680-4 |
| repeat | WD40 repeat | 495 - 579 | IPR001680-5 |
| conserved_site | WD40 repeat, conserved site | 304 - 318 | IPR019775 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| catalytic step 2 spliceosome | A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| U2-type catalytic step 2 spliceosome | A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| embryonic brain development | The process occurring during the embryonic phase whose specific outcome is the progression of the brain over time, from its formation to the mature structure. |
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O60508 | CDC40 | Pre-mRNA-processing factor 17 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSAAIAALAA | SYGSGSGSES | DSDSEGSRCP | LPAADSLMHL | TKSPSAKLSL | TVAVDSAPEV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AVKEDLETGV | HLDPAVKEVQ | YNPTYETMFA | PEFGPENPFR | TQQMAAPRNM | LSGYAEPAHI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NDFMFEQQRR | TFATYGYALD | PSLDNHQVSA | KYIGSVEEAE | KNQGLTVFET | GQKKTEKRKK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FKENDASNID | GFLGPWAKYV | DEKDVAKPSE | EEQKELDEIT | AKRQKKGKQE | EEKPGEEKTI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LHVKEMYDYQ | GRSYLHIPQD | VGVNLRSSVP | PEKCYLPKKQ | IHVWSGHTKG | VSAVRLFPLS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GHLLLSCSMD | CKIKLWEVYG | DRRCLRTFIG | HSKAVRDICF | NTAGTQFLSA | AYDRYLKLWD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TETGQCISRF | TNRKVPYCVK | FNPDEDKQNL | FVAGMSDKKI | VQWDIRSGEI | VQEYDRHLGA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VNTIVFVDEN | RRFVSTSDDK | SLRVWEWDIP | VDFKYIAEPS | MHSMPAVTLS | PNGKWLACQS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| MDNQILIFGA | QNRFRLNKKK | IFKGHMVAGY | ACQVDFSPDM | SYVISGDGNG | KLNIWDWKTT |
| 550 | 560 | 570 | |||
| KLYSRFKAHD | KVCIGAVWHP | HETSKVITCG | WDGLIKLWD |