Q9DB32

PR
Gene name
Haghl
Protein name
Hydroxyacylglutathione hydrolase-like protein
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:68977
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

161-234 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9DB32

Entry ID Method Resolution Chain Position Source
AF-Q9DB32-F1 Predicted AlphaFoldDB

21 variants for Q9DB32

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389442545 9 L>F No EVA
rs3389435215 15 Y>H No EVA
rs3389442585 17 I>N No EVA
rs259543077 28 I>V No EVA
rs221920152 49 M>T No EVA
rs235256193 69 I>M No EVA
rs220554553 76 L>M No EVA
rs3389451085 98 G>E No EVA
rs3389422508 105 L>F No EVA
rs249217741 123 D>E No EVA
rs253680779 157 A>V No EVA
rs3389436880 189 C>R No EVA
rs3407365728 232 V>I No EVA
rs229876424 238 Q>E No EVA
rs3389443580 258 A>D No EVA
rs3389413399 264 P>Q No EVA
rs3389454415 268 A>V No EVA
rs3389404434 276 L>H No EVA
rs214173069 280 H>R No EVA
rs245095178 281 Q>K No EVA
rs227434783 282 K>E No EVA

No associated diseases with Q9DB32

3 regional properties for Q9DB32

Type Name Position InterPro Accession
domain Metallo-beta-lactamase 11 - 173 IPR001279
domain Hydroxyacylglutathione hydrolase, C-terminal domain 174 - 254 IPR032282
domain Hydroxyacylglutathione hydrolase, MBL domain 4 - 173 IPR035680

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
hydroxyacylglutathione hydrolase activity Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q0VBY3 HAGHL Hydroxyacylglutathione hydrolase-like protein Bos taurus (Bovine) PR
10 20 30 40 50 60
MKVKVIPVLE DNYMYLIIEE HTREAVAIDV AVAERLLEIA GREGVSLTMV LSTHHHWDHT
70 80 90 100 110 120
RGNAELAHIL PGLAVLGADE RICALTRRLE HGEGLQFGAI HVRCLLTPGH TSGHMSYFLW
130 140 150 160 170 180
EDDCPDSPAL FSGDALSVAG CGWHLEDTAQ QMYQSLAKTL GTLPPETKVF CGHEHTLSNL
190 200 210 220 230 240
EFAQKVEPCN EHVQAKLSWA QERDDEDIPT VPSTLGEELM YNPFLRVTED AVRAFTGQVA
250 260 270 280
PAQVLEALCR ERARFQPAVE PPQPQVRALL ALQWGLLSTH QKK