Q9DB30

PR
Gene name
Phkg2
Protein name
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
Names
PHK-gamma-LT, PHK-gamma-T, Phosphorylase kinase subunit gamma-2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:68961
EC number
2.7.11.19: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-47 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9DB30

Entry ID Method Resolution Chain Position Source
AF-Q9DB30-F1 Predicted AlphaFoldDB

15 variants for Q9DB30

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3398531857 34 V>M No EVA
rs3388922244 50 F>I No EVA
rs3388949318 53 K>T No EVA
rs3388945649 54 I>T No EVA
rs13473876 58 S>P No EVA
rs3388945237 69 E>D No EVA
rs3388950350 107 F>S No EVA
rs3388922293 187 L>M No EVA
rs217700634 227 L>M No EVA
rs3388934402 302 L>F No EVA
rs3388922301 313 W>C No EVA
rs3388934405 358 Y>H No EVA
rs257188526 382 F>V No EVA
rs221160548 397 T>A No EVA
rs241452660 401 A>V No EVA

No associated diseases with Q9DB30

6 regional properties for Q9DB30

Type Name Position InterPro Accession
domain Protein kinase domain 98 - 366 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 98 - 357 IPR001245
domain SH3 domain 16 - 81 IPR001452
active_site Serine/threonine-protein kinase, active site 218 - 230 IPR008271
binding_site Protein kinase, ATP binding site 104 - 125 IPR017441
domain MLK1-3, SH3 domain 20 - 76 IPR035779

Functions

Description
EC Number 2.7.11.19 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
enzyme binding Binding to an enzyme, a protein with catalytic activity.
phosphorylase kinase activity Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a.

4 GO annotations of biological process

Name Definition
glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
glycogen catabolic process The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
glycogen metabolic process The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages.
protein phosphorylation The process of introducing a phosphate group on to a protein.

18 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2KJ16 PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform Bos taurus (Bovine) PR
Q16816 PHKG1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Homo sapiens (Human) PR
P15735 PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform Homo sapiens (Human) PR
P07934 Phkg1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Mus musculus (Mouse) SS
P28652 Camk2b Calcium/calmodulin-dependent protein kinase type II subunit beta Mus musculus (Mouse) SS
P11798 Camk2a Calcium/calmodulin-dependent protein kinase type II subunit alpha Mus musculus (Mouse) PR
Q923T9 Camk2g Calcium/calmodulin-dependent protein kinase type II subunit gamma Mus musculus (Mouse) SS
Q6PHZ2 Camk2d Calcium/calmodulin-dependent protein kinase type II subunit delta Mus musculus (Mouse) SS
Q8VCR8 Mylk2 Myosin light chain kinase 2, skeletal/cardiac muscle Mus musculus (Mouse) SS
Q3UIZ8 Mylk3 Myosin light chain kinase 3 Mus musculus (Mouse) SS
Q91YA2 Pskh1 Serine/threonine-protein kinase H1 Mus musculus (Mouse) SS
Q9QYK9 Pnck Calcium/calmodulin-dependent protein kinase type 1B Mus musculus (Mouse) PR
Q91VB2 Camk1g Calcium/calmodulin-dependent protein kinase type 1G Mus musculus (Mouse) SS
Q8BW96 Camk1d Calcium/calmodulin-dependent protein kinase type 1D Mus musculus (Mouse) SS
Q3UHL1 Camkv CaM kinase-like vesicle-associated protein Mus musculus (Mouse) SS
Q91YS8 Camk1 Calcium/calmodulin-dependent protein kinase type 1 Mus musculus (Mouse) SS
P13286 Phkg1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Rattus norvegicus (Rat) SS
P31325 Phkg2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MTLDVGPEDE LPDWAAAKEF YQKYDPKDII GRGVSSVVRR CVHRATGDEF AVKIMEVSAE
70 80 90 100 110 120
RLSLEQLEEV RDATRREMHI LRQVAGHPHI ITLIDSYESS SFMFLVFDLM RKGELFDYLT
130 140 150 160 170 180
EKVALSEKET RSIMRSLLEA VSFLHANNIV HRDLKPENIL LDDNMQIRLS DFGFSCHLEA
190 200 210 220 230 240
GEKLRELCGT PGYLAPEILK CSMDETHPGY GKEVDLWACG VILFTLLAGS PPFWHRRQIL
250 260 270 280 290 300
MLRMIMEGQY QFTSPEWDDR SNTVKDLISK LLQVDPEARL TAEQALQHPF FERCEGSQPW
310 320 330 340 350 360
NLTPRQRFRV AVWTILAAGR VALSSHRLRP LTKNALLRDP YALRPVRRLI DNCAFRLYGH
370 380 390 400
WVKKGEQQNR AALFQHQPPR LFPIAATELE GDSGAITEDE ATLVRS