Q9D8C8

PR
Gene name
Ppp1r35
Protein name
Protein phosphatase 1 regulatory subunit 35
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:69871
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-128 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9D8C8

Entry ID Method Resolution Chain Position Source
AF-Q9D8C8-F1 Predicted AlphaFoldDB

11 variants for Q9D8C8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs237995181 3 G>D No EVA
rs262319956 12 I>T No EVA
rs231003309 14 G>S No EVA
rs265548378 74 G>R No EVA
rs227684049 90 E>K No EVA
rs3396035753 160 N>K No EVA
rs3395899845 161 V>A No EVA
rs254631582 183 N>K No EVA
rs3396266285 184 A>V No EVA
rs3388795747 224 E>K No EVA
rs3388793685 228 L>F No EVA

No associated diseases with Q9D8C8

No regional properties for Q9D8C8

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9D8C8

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
  • Recruited to the nascent daughter centriole early in the duplication cycle and localizes to the proximal centriolar lumen just above the cartwheel
  • Co-localizes with RTTN at the centriole
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
centriole A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
phosphatase binding Binding to a phosphatase.
protein phosphatase inhibitor activity Binds to and stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins.

4 GO annotations of biological process

Name Definition
negative regulation of phosphatase activity Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
notochord morphogenesis The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.
positive regulation of centriole elongation Any process that activates or increases the frequency, rate or extent of centriole elongation.
positive regulation of cilium assembly Any process that activates or increases the frequency, rate or extent of the formation of a cilium.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q0P427 ppp1r35 Protein phosphatase 1 regulatory subunit 35 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MMGFGASALE SIEGEEALEV PGPPPEPRAP EPRAPEPEPG LDLSLSPSPL PESPKARKSS
70 80 90 100 110 120
PGQRKGRRGG SRRGRQVRFQ LAPPSPVRSE PLLVAGAPGD DHELEAPALQ SSLALSLELQ
130 140 150 160 170 180
NARAAVASGQ FDASKAVEEQ LRKSFRTRCA LEETVAEGLN VPRSKRLYRD LVSLQVPEEQ
190 200 210 220 230 240
VLNAALREKL AMLPPQPRAP PLKEVLGPGP DMTMLCNPDS LWSESPHLTV DGLPPLRLQA
250
RPRPSEDTFL MHRMLRRWEA