Q9D7R2

PR
Gene name
Pmepa1 (N4wbp4, Tmepai)
Protein name
Protein TMEPAI
Names
NEDD4 WW domain-binding protein 4, Prostate transmembrane protein androgen induced 1, Transmembrane prostate androgen-induced protein
Species
Mus musculus (Mouse)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

28-260 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9D7R2

Entry ID Method Resolution Chain Position Source
AF-Q9D7R2-F1 Predicted AlphaFoldDB

No variants for Q9D7R2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9D7R2

No associated diseases with Q9D7R2

No regional properties for Q9D7R2

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9D7R2

Functions

Description
EC Number
Subcellular Localization
  • Early endosome membrane ; Single-pass membrane protein
  • Golgi apparatus membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
early endosome membrane The lipid bilayer surrounding an early endosome.
endosome membrane The lipid bilayer surrounding an endosome.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

2 GO annotations of molecular function

Name Definition
R-SMAD binding Binding to a receptor-regulated SMAD signaling protein.
WW domain binding Binding to a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions.

3 GO annotations of biological process

Name Definition
negative regulation of pathway-restricted SMAD protein phosphorylation Any process that decreases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
negative regulation of SMAD protein complex assembly Any process that decreases the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins.
negative regulation of transforming growth factor beta receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q969W9 PMEPA1 Protein TMEPAI Homo sapiens (Human) PR
10 20 30 40 50 60
MSPARATAQR SLFPSMEITE LEFVQIVVIV VVMMVMVVMI TCLLSHYKLS ARSFISRHSQ
70 80 90 100 110 120
ARRRDDGLSS EGCLWPSEST VSGGMPEPQV YAPPRPTDRL AVPPFIQRSR FQPTYPYLQH
130 140 150 160 170 180
EIALPPTISL SDGEEPPPYQ GPCTLQLRDP EQQLELNRES VRAPPNRTIF DSDLIDSTML
190 200 210 220 230 240
GGPCPPSSNS GISATCYSSG GRMEGPPPTY SEVIGHYPGS SFQHQQSNGP SSLLEGTRLH
250
HSHIAPLENK EKEKQKGHPL