Q9D7P6

PR
Gene name
Iscu (Nifun)
Protein name
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
Names
NifU-like N-terminal domain-containing protein, NifU-like protein
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:66383
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-56 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q9D7P6

Entry ID Method Resolution Chain Position Source
1WFZ NMR - A 45-161 PDB
AF-Q9D7P6-F1 Predicted AlphaFoldDB

5 variants for Q9D7P6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3396077086 108 E>Q No EVA
rs3395675129 108 E>V No EVA
rs3396016094 110 V>L No EVA
rs3388785868 113 K>R No EVA
rs3388773914 125 D>E No EVA

No associated diseases with Q9D7P6

1 regional properties for Q9D7P6

Type Name Position InterPro Accession
domain NIF system FeS cluster assembly, NifU, N-terminal 16 - 166 IPR002871

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
iron-sulfur cluster assembly complex A protein complex capable of assembling an iron-sulfur (Fe-S) cluster.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
2 iron, 2 sulfur cluster binding Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
ferrous iron binding Binding to a ferrous iron ion, Fe(II).
molecular adaptor activity The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.

7 GO annotations of biological process

Name Definition
[4Fe-4S] cluster assembly The incorporation of four iron atoms and four sulfur atoms into an iron-sulfur cluster.
cellular iron ion homeostasis Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
iron ion homeostasis Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.
iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
negative regulation of iron ion import across plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of iron ions import across plasma membrane.
positive regulation of aconitate hydratase activity Any process that activates or increases the frequency, rate or extent of aconitate hydratase activity.
positive regulation of mitochondrial electron transport, NADH to ubiquinone Any process that activates or increases the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9H1K1 ISCU Iron-sulfur cluster assembly enzyme ISCU, mitochondrial Homo sapiens (Human) PR
10 20 30 40 50 60
MAAATGAGRL RRAASALLLR SPRLPARELS APARLYHKKV VDHYENPRNV GSLDKTSKNV
70 80 90 100 110 120
GTGLVGAPAC GDVMKLQIQV DEKGKIVDAR FKTFGCGSAI ASSSLATEWV KGKTVEEALT
130 140 150 160
IKNTDIAKEL CLPPVKLHCS MLAEDAIKAA LADYKLKQES KKEEPEKQ