Q9D659
PR
Gene name |
Vsir |
Protein name |
V-type immunoglobulin domain-containing suppressor of T-cell activation |
Names |
Platelet receptor Gi24, V-set domain-containing immunoregulatory receptor, V-set immunoregulatory receptor |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:74048 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9D659
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9D659-F1 | Predicted | AlphaFoldDB |
14 variants for Q9D659
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs243109406 | 18 | L>V | No | EVA | |
| rs3389087709 | 20 | A>D | No | EVA | |
| rs3401369435 | 39 | Y>* | No | EVA | |
| rs3389101754 | 39 | Y>* | No | EVA | |
| rs13472401 | 68 | I>V | No | EVA | |
| rs3389096585 | 105 | K>R | No | EVA | |
| rs215021273 | 133 | R>H | No | EVA | |
| rs3389110798 | 183 | Q>* | No | EVA | |
| rs3389102215 | 190 | A>T | No | EVA | |
| rs3389102207 | 191 | A>E | No | EVA | |
| rs3401302624 | 225 | Q>* | No | EVA | |
| rs3389101300 | 278 | D>E | No | EVA | |
| rs3389110769 | 289 | G>W | No | EVA | |
| rs228093426 | 291 | V>I | No | EVA |
No associated diseases with Q9D659
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| external side of plasma membrane | The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| endopeptidase activator activity | Binds to and increases the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. |
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| identical protein binding | Binding to an identical protein or proteins. |
18 GO annotations of biological process
| Name | Definition |
|---|---|
| BMP signaling pathway | The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| negative regulation of alpha-beta T cell activation | Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation. |
| negative regulation of CD4-positive, alpha-beta T cell proliferation | Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation. |
| negative regulation of CD8-positive, alpha-beta T cell proliferation | Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation. |
| negative regulation of interferon-gamma production | Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. |
| negative regulation of interleukin-10 production | Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production. |
| negative regulation of interleukin-17 production | Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. |
| negative regulation of T cell cytokine production | Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production. |
| negative regulation of tumor necrosis factor production | Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production. |
| positive regulation of BMP signaling pathway | Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity. |
| positive regulation of cell migration | Any process that activates or increases the frequency, rate or extent of cell migration. |
| positive regulation of collagen catabolic process | Any process that activates or increases the frequency, rate or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. |
| positive regulation of endopeptidase activity | Any process that increases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| positive regulation of regulatory T cell differentiation | Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells. |
| positive regulation of stem cell differentiation | Any process that activates or increases the frequency, rate or extent of stem cell differentiation. |
| stem cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. |
| zymogen activation | The proteolytic processing of an inactive enzyme to an active form. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGVPAVPEAS | SPRWGTLLLA | IFLAASRGLV | AAFKVTTPYS | LYVCPEGQNA | TLTCRILGPV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SKGHDVTIYK | TWYLSSRGEV | QMCKEHRPIR | NFTLQHLQHH | GSHLKANASH | DQPQKHGLEL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ASDHHGNFSI | TLRNVTPRDS | GLYCCLVIEL | KNHHPEQRFY | GSMELQVQAG | KGSGSTCMAS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NEQDSDSITA | AALATGACIV | GILCLPLILL | LVYKQRQVAS | HRRAQELVRM | DSNTQGIENP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GFETTPPFQG | MPEAKTRPPL | SYVAQRQPSE | SGRYLLSDPS | TPLSPPGPGD | VFFPSLDPVP |
| DSPNSEAI |