Q9D4J1
Gene name |
Efhd1 (Sws2) |
Protein name |
EF-hand domain-containing protein D1 |
Names |
EF-hand domain-containing protein 1, Mitocalcin, Swiprosin-2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:98363 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for Q9D4J1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7CLT | X-ray | 207 A | A | 69-199 | PDB |
| 7YGV | X-ray | 280 A | A | 69-193 | PDB |
| 7YGW | X-ray | 172 A | A | 69-193 | PDB |
| AF-Q9D4J1-F1 | Predicted | AlphaFoldDB |
9 variants for Q9D4J1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388483384 | 127 | Q>* | No | EVA | |
| rs3390303310 | 128 | T>A | No | EVA | |
| rs3390289479 | 129 | H>Q | No | EVA | |
| rs3390270103 | 130 | L>V | No | EVA | |
| rs3390251424 | 133 | K>R | No | EVA | |
| rs3388485049 | 153 | L>Q | No | EVA | |
| rs3388485750 | 204 | S>R | No | EVA | |
| rs3388485033 | 205 | K>* | No | EVA | |
| rs3388485779 | 228 | Q>H | No | EVA |
No associated diseases with Q9D4J1
1 regional properties for Q9D4J1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Exocyst complex component Sec8, N-terminal | 45 - 143 | IPR007191 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| calcium ion sensor activity | Binding to and responding, e.g. by conformational change, to changes in the cellular level of calcium ions (Ca2+). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| neuron projection development | The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| regulation of cellular hyperosmotic salinity response | Any process that modulates the frequency, rate or extent of cellular hyperosmotic salinity response. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9VJ26 | Swip-1 | EF-hand domain-containing protein D2 homolog | Drosophila melanogaster (Fruit fly) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSEELACKL | QRRLRLEVRA | ETDQGDPQPA | PCDAPAGHPE | PEPPARAPTA | SADSELNLKL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SRRLDIHQGT | ARPGRSKVFN | PYTEFPEFSR | RLLKDLEKMF | KTYDAGRDGF | IDLMELKLMM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EKLGAPQTHL | GLKSMIKEVD | EDFDGKLSFR | EFLLIFHKAA | AGELQEDSGL | LALAKFSEID |
| 190 | 200 | 210 | 220 | 230 | |
| VALEGVRGAK | NFFEAKAQAL | SCSSKFEAEL | KAEQEERKRE | EEARRLRQAA | FRELKAAFSA |