Q9D4H1
PR
Gene name |
Exoc2 (Sec5, Sec5l1) |
Protein name |
Exocyst complex component 2 |
Names |
Exocyst complex component Sec5 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:66482 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q9D4H1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1HK6 | NMR | - | A | 5-97 | PDB |
| AF-Q9D4H1-F1 | Predicted | AlphaFoldDB |
39 variants for Q9D4H1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389268335 | 78 | T>S | No | EVA | |
| rs232871090 | 103 | Q>P | No | EVA | |
| rs3389243604 | 152 | L>I | No | EVA | |
| rs3389277880 | 216 | Q>* | No | EVA | |
| rs3389283611 | 246 | L>F | No | EVA | |
| rs3389272079 | 252 | T>S | No | EVA | |
| rs3389206240 | 256 | L>M | No | EVA | |
| rs226138701 | 289 | N>S | No | EVA | |
| rs3389268334 | 332 | I>N | No | EVA | |
| rs3389283633 | 337 | E>K | No | EVA | |
| rs3389274295 | 384 | L>H | No | EVA | |
| rs3389274358 | 388 | C>G | No | EVA | |
| rs242162969 | 399 | H>L | No | EVA | |
| rs220977349 | 402 | P>L | No | EVA | |
| rs3389272109 | 403 | H>N | No | EVA | |
| rs3389274319 | 432 | S>R | No | EVA | |
| rs3389272068 | 478 | L>P | No | EVA | |
| rs3389287392 | 483 | A>G | No | EVA | |
| rs3404018327 | 505 | M>L | No | EVA | |
| rs3403792520 | 507 | Q>L | No | EVA | |
| rs3389268353 | 550 | H>Y | No | EVA | |
| rs3389272110 | 568 | P>S | No | EVA | |
| rs3389268352 | 573 | Q>L | No | EVA | |
| rs1131790323 | 592 | Q>* | No | EVA | |
| rs3389293132 | 646 | F>V | No | EVA | |
| rs3389283659 | 663 | M>V | No | EVA | |
| rs3389243613 | 676 | K>E | No | EVA | |
| rs3389243592 | 689 | D>N | No | EVA | |
| rs3389243573 | 707 | S>* | No | EVA | |
| rs3389276088 | 709 | Q>E | No | EVA | |
| rs3389250886 | 711 | L>F | No | EVA | |
| rs3389268378 | 717 | N>Y | No | EVA | |
| rs3389283614 | 727 | L>I | No | EVA | |
| rs3402612270 | 764 | I>N | No | EVA | |
| rs3404116816 | 789 | C>Y | No | EVA | |
| rs3404195464 | 792 | P>A | No | EVA | |
| rs3404022326 | 792 | P>Q | No | EVA | |
| rs3403579160 | 847 | S>C | No | EVA | |
| rs3403930781 | 848 | R>* | No | EVA |
No associated diseases with Q9D4H1
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| exocyst | A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. |
| Flemming body | A cell part that is the central region of the midbody characterized by a gap in alpha-tubulin staining. It is a dense structure of antiparallel microtubules from the central spindle in the middle of the intercellular bridge. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| protein N-terminus binding | Binding to a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. |
| small GTPase binding | Binding to a small monomeric GTPase. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| exocytosis | A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. |
| Golgi to plasma membrane transport | The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis. |
| membrane fission | A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes. |
| mitotic cytokinesis | A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. |
| positive regulation of exocytosis | Any process that activates or increases the frequency, rate or extent of exocytosis. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of entry of bacterium into host cell | Any process that modulates the frequency, rate or extent of entry of bacterium into host cell. |
| vesicle docking involved in exocytosis | The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. |
| vesicle tethering involved in exocytosis | The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96KP1 | EXOC2 | Exocyst complex component 2 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSRSRQPPLV | TGISPNEGIP | WTKVTIRGEN | LGTGPTDLIG | LTICGHNCLL | TAEWMSASKI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VCRVGQAKND | KGDIIVTTKS | GGKGTSTVSF | KLLKPEKIGI | LDQSAVWVDE | MNYYDMRTDR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NKGIPPLSLR | PANPLGIEIE | KCKLPQKNLE | VLFHGMSADF | TSENFSAAWY | LIENHSTTSF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EQLKMAVTNL | KRQANKKSEG | SLAYVKGGLS | TFFEAQDALS | AIHQKLEADG | TEKVEGSMTQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KLENVLNRAS | NTADTLFQEV | LGRKDKADST | RNALNVLQRF | KFLFNLPLNI | KRNIQKGDYD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VVINDYEKAK | SLFGKTEVQV | FKKYYAEVEA | GIEDLRELLL | KKLLETPSTL | HDQKRYIRYL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SDLHAPGDPA | WQCIGAQHKW | TLKLMQDCKE | GHMKSLKGHP | GPHSPMLDLD | NDVRPSVLGH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LSQTASLKRG | SSFQSGRDDT | WRYKTPHRVA | FVEKLTKLVL | SQLPNFWKLW | ISYVNGSLFS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ETAEKSGQSE | RSKNVRQRQN | DFKKMIQEVM | HSLVKLIRGA | LLPLSLREGD | GRQYGGWEVQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AELSGQWLAH | VIQTIRLTYE | SLTALEIPND | MLQIIQDLIL | DLRIRCIMVT | LQHTAEEIKR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LAEKEDWVVD | NEGLTSLPCQ | FEQSIVHSLQ | SLKGVVDCKP | GEASVFQQPK | TQEEVCQLCI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| NIMQVFIYCL | EQLSTKPDAD | IDTTHLSVDV | SSPDLFGSIH | EDFSLTSEQR | LLIVLSNCCY |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LERHTFLNIA | EHFEKHNFQG | IEKITQVSMA | SLKELDQRLF | ENYIELKADP | IVGSLEPGIY |
| 790 | 800 | 810 | 820 | 830 | 840 |
| AGYFDWKDCL | PPAGVRNYLK | EALVNIIAVH | AEVFTISKEL | VPRVLARVVE | AVSEELSRLM |
| 850 | 860 | 870 | 880 | 890 | 900 |
| QCVSSFSRNG | ALQARLEICA | LRDTVAIYLT | SESRSSFKQA | LEALPQLASG | ADKKSLEELL |
| 910 | 920 | ||||
| NKFKSSMHLQ | LTCFQAASPA | VMKT |