Q9D2Q2
Gene name |
Trmt44 (Mettl19) |
Protein name |
Probable tRNA (uracil-O(2)-)-methyltransferase |
Names |
Methyltransferase-like protein 19 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:78890 |
EC number |
2.1.1.211: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9D2Q2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9D2Q2-F1 | Predicted | AlphaFoldDB |
69 variants for Q9D2Q2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388753456 | 29 | E>K | No | EVA | |
| rs3388745490 | 39 | C>Y | No | EVA | |
| rs252489227 | 47 | G>V | No | EVA | |
| rs233356287 | 64 | Q>L | No | EVA | |
| rs214949957 | 68 | L>P | No | EVA | |
| rs251492906 | 69 | E>D | No | EVA | |
| rs3388742174 | 83 | S>* | No | EVA | |
| rs3388739525 | 107 | Q>* | No | EVA | |
| rs3388756032 | 109 | L>I | No | EVA | |
| rs237231582 | 121 | C>Y | No | EVA | |
| rs3388756079 | 143 | I>T | No | EVA | |
| rs3388762110 | 160 | V>I | No | EVA | |
| rs3395074282 | 181 | N>E | No | EVA | |
| rs3388753814 | 186 | T>A | No | EVA | |
| rs3388757649 | 233 | K>E | No | EVA | |
| rs3388742147 | 237 | W>* | No | EVA | |
| rs3388762136 | 237 | W>* | No | EVA | |
| rs3388756648 | 238 | A>V | No | EVA | |
| rs3388745553 | 239 | V>G | No | EVA | |
| rs3388756665 | 252 | L>M | No | EVA | |
| rs32627357 | 254 | S>C | No | EVA | |
| rs3388757199 | 261 | M>I | No | EVA | |
| rs3388753373 | 281 | D>V | No | EVA | |
| rs3388753417 | 293 | A>V | No | EVA | |
| rs3388758631 | 320 | C>* | No | EVA | |
| rs3388757711 | 341 | I>S | No | EVA | |
| rs261953412 | 349 | M>T | No | EVA | |
| rs265505569 | 366 | E>K | No | EVA | |
| rs864279523 | 369 | F>Y | No | EVA | |
| rs3388750718 | 371 | G>D | No | EVA | |
| rs3388750673 | 394 | S>P | No | EVA | |
| rs3395410848 | 410 | F>I | No | EVA | |
| rs3395451266 | 410 | F>L | No | EVA | |
| rs3395384052 | 415 | Q>K | No | EVA | |
| rs254932046 | 463 | T>S | No | EVA | |
| rs32633300 | 477 | T>A | No | EVA | |
| rs3388753422 | 478 | R>Q | No | EVA | |
| rs3388750763 | 487 | P>S | No | EVA | |
| rs3388728082 | 495 | H>Q | No | EVA | |
| rs223818090 | 495 | H>R | No | EVA | |
| rs237470087 | 495 | H>Y | No | EVA | |
| rs3388748421 | 496 | A>S | No | EVA | |
| rs224273761 | 516 | V>I | No | EVA | |
| rs32633303 | 517 | N>D | No | EVA | |
| rs32634165 | 528 | A>D | No | EVA | |
| rs218788421 | 530 | E>D | No | EVA | |
| rs248074754 | 534 | G>E | No | EVA | |
| rs235065389 | 537 | A>T | No | EVA | |
| rs3388748371 | 545 | F>S | No | EVA | |
| rs3388748366 | 556 | N>T | No | EVA | |
| rs3388753783 | 569 | V>I | No | EVA | |
| rs237580165 | 579 | R>S | No | EVA | |
| rs225161585 | 580 | K>R | No | EVA | |
| rs214783042 | 585 | G>A | No | EVA | |
| rs250338217 | 591 | S>N | No | EVA | |
| rs32634167 | 592 | L>M | No | EVA | |
| rs255775403 | 594 | P>T | No | EVA | |
| rs1132944257 | 620 | R>Q | No | EVA | |
| rs253973811 | 620 | R>W | No | EVA | |
| rs3388742148 | 621 | E>V | No | EVA | |
| rs3388753449 | 633 | H>Q | No | EVA | |
| rs263925342 | 640 | N>S | No | EVA | |
| rs32635335 | 649 | R>W | No | EVA | |
| rs231415943 | 650 | Q>R | No | EVA | |
| rs32635337 | 662 | Q>R | No | EVA | |
| rs3388753465 | 671 | T>A | No | EVA | |
| rs3411762407 | 681 | P>S | No | EVA | |
| rs3388762118 | 692 | P>L | No | EVA | |
| rs3388753390 | 695 | H>D | No | EVA |
No associated diseases with Q9D2Q2
1 regional properties for Q9D2Q2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Zinc finger, CCCH-type | 669 - 698 | IPR000571 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.211 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| tRNA (uracil) methyltransferase activity | Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule. |
| tRNA (uracil-2'-O-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methyluracil. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tRNA methylation | The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8IYL2 | TRMT44 | Probable tRNA (uracil-O(2)-)-methyltransferase | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEELGRVRLS | DPDALLPAGF | WAAVTVWLER | PQVANKRLCG | ARMEARGRTL | RSHAQAECGP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RQGQGHGLER | EPGQASPKGE | PESGPRASRE | GTAPAADLNS | LWDRVSQSLV | HANPEMLAFL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CGPSLGPQPE | AAQELDLILR | TVIPKASPHS | PLTEPKKELV | VQDVSSGSVT | FLPLEEDNEG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NLEVKTSNVY | QLHLHHNEGE | WFISVLIFCP | ERWHSDGVVY | PKPAWLGEEL | LSKLARWAVE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NRKSEFKSTL | SLVSILRYSR | MYQELKEKYR | DMVKVWPEVT | DPEKFVYEDV | AIATYLLILW |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EEERAEKGVT | TKQSFVDLGC | GNGLLVHILS | NEGHPGRGID | IRRRKIWDMY | GPQTQLEEGS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ITPSDETLFP | GVDWLIGNHS | DELTPWIPVI | AARSSYTCRF | FVLPCCFFDF | VGRYQRQQSR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KTQYREYLDF | VLEVGLSCGF | HVQEDCLRIP | STKRVCLIGK | SRTYPPSAEV | WMDEQRTRYL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HSRQGHPQSR | PGGAHAPSAP | QTAAHDAGLQ | DSCRTVNAGS | ECVLEGLAAE | RGAGAPAPGL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| WVPGFCPREK | AERVRNCAAL | PRDFVDQVVL | QVANLLLDRK | KFNTGNSEAR | SLKPWNGGGS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LSLAEVAAEL | NSETLQRLKR | ECGGLQTLLK | NSHQVFEVLN | GRVHIRDWRQ | ELQRGKPPEA |
| 670 | 680 | 690 | 700 | 710 | |
| KQNLSAAVFK | TRICWFFAHH | PDGCVLPAAQ | CPFAHGPEEL | RLSQTLKKQR | QAP |