Q9D1J1
Gene name |
Necap2 |
Protein name |
Adaptin ear-binding coat-associated protein 2 |
Names |
NECAP endocytosis-associated protein 2, NECAP-2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:66147 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for Q9D1J1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6OWO | EM | 320 A | N | 1-266 | PDB |
| 6OXL | EM | 350 A | N | 1-266 | PDB |
| AF-Q9D1J1-F1 | Predicted | AlphaFoldDB |
7 variants for Q9D1J1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388723954 | 82 | E>* | No | EVA | |
| rs3388727441 | 115 | A>S | No | EVA | |
| rs3388732281 | 149 | D>G | No | EVA | |
| rs3388702924 | 180 | T>S | No | EVA | |
| rs49968394 | 225 | A>T | No | EVA | |
| rs27588310 | 242 | I>L | No | EVA | |
| rs3388702883 | 251 | G>W | No | EVA |
No associated diseases with Q9D1J1
1 regional properties for Q9D1J1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | NECAP, PHear domain | 6 - 162 | IPR012466 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| clathrin vesicle coat | A clathrin coat found on a vesicle. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEESEYESVL | CVKPEVHVYR | IPPRATNRGY | RASEWQLDQP | SWSGRLRITA | KGKVAYIKLE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DRTSGELFAQ | APVDQFPGTA | VESVTDSSRY | FVIRIEDGNG | RRAFIGLGFG | DRGDAFDFNV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ALQDHFKWVK | QQCEFAKQAQ | NPDEGPKLDL | GFKDGQTIKI | NIANMRKKEG | AAGTPRARPT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SAGGLSLLPP | PPGGKSSTVI | PPSGEQLSVG | GSLVQPAVVS | GSGGATELWP | QSKPAAAATA |
| 250 | 260 | ||||
| DIWGDFTKST | GSPSSQSQPG | TGWVQF |