Q9D180

PR
Gene name
Cfap57
Protein name
Cilia- and flagella-associated protein 57
Names
WD repeat-containing protein 65
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:68625
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

865-972 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9D180

Entry ID Method Resolution Chain Position Source
AF-Q9D180-F1 Predicted AlphaFoldDB

65 variants for Q9D180

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388693235 60 M>V No EVA
rs3388713399 66 S>N No EVA
rs3388710942 78 V>E No EVA
rs229872085 84 V>I No EVA
rs3388702060 86 I>N No EVA
rs3388704400 110 F>S No EVA
rs3388709750 125 Q>* No EVA
rs3388713385 136 W>C No EVA
rs3388706255 139 E>G No EVA
rs3388705856 149 A>V No EVA
rs3388710887 151 S>N No EVA
rs3388702501 175 G>E No EVA
rs3388707967 189 Q>L No EVA
rs3388693246 190 I>N No EVA
rs3388705519 199 N>T No EVA
rs3388704381 223 F>I No EVA
rs3388702122 229 R>C No EVA
rs239769053 239 S>P No EVA
rs249568477 271 D>E No EVA
rs223276093 271 D>H No EVA
rs3388693241 329 S>C No EVA
rs3388702458 364 I>N No EVA
rs3388706289 461 D>A No EVA
rs3388707724 504 I>F No EVA
rs253181476 506 I>N No EVA
rs3388702531 522 D>V No EVA
rs3388702526 550 V>M No EVA
rs3388710940 554 C>Y No EVA
rs27510786 558 S>A No EVA
rs3388707365 593 D>N No EVA
rs3388707370 629 E>K No EVA
rs3388707314 643 M>K No EVA
rs217219867 651 F>L No EVA
rs3388695462 654 T>R No EVA
rs3388699061 655 V>F No EVA
rs3388695392 677 E>V No EVA
rs3388685622 678 R>SDG* No EVA
rs3388702149 689 T>I No EVA
rs3388702126 707 V>E No EVA
rs3412928420 738 Q>H No EVA
rs3388702523 759 I>S No EVA
rs3388705500 789 L>P No EVA
rs3388706283 824 E>Q No EVA
rs27510900 839 G>S No EVA
rs3388693182 857 E>* No EVA
rs3388705877 862 I>N No EVA
rs3388705467 869 E>D No EVA
rs3388707690 905 L>M No EVA
rs3388693264 913 T>S No EVA
rs3388704380 920 K>E No EVA
rs3388695393 951 I>V No EVA
rs3388685619 954 K>E No EVA
rs3388704472 969 E>V No EVA
rs3388702130 1045 L>P No EVA
rs3388707331 1064 Q>* No EVA
rs216185161 1067 G>R No EVA
rs3388710902 1087 V>M No EVA
rs3388708017 1091 G>W No EVA
rs3410870036 1143 I>F No EVA
rs3388707727 1147 R>C No EVA
rs3388702466 1155 S>T No EVA
rs3388702142 1164 L>M No EVA
rs3388707676 1169 K>M No EVA
rs27510961 1170 T>A No EVA
rs3388707372 1238 V>A No EVA

No associated diseases with Q9D180

5 regional properties for Q9D180

Type Name Position InterPro Accession
repeat WD40 repeat 140 - 181 IPR001680-1
repeat WD40 repeat 329 - 365 IPR001680-2
repeat WD40 repeat 376 - 456 IPR001680-3
repeat WD40 repeat 500 - 581 IPR001680-4
repeat WD40 repeat 626 - 665 IPR001680-5

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton, cilium axoneme
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

No GO annotations of biological process

Name Definition
No GO annotations for biological process

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96MR6 CFAP57 Cilia- and flagella-associated protein 57 Homo sapiens (Human) PR
10 20 30 40 50 60
MSTVVAQALH VFGLRPHVTN NVFFFDEQII IFPSGNHCVK YNIDQKWQKF IAGSDKSQGM
70 80 90 100 110 120
LALAISPNRR YLAISETVQE KPAVTIYELS SIPCRKRKVL NNFDFQVQKF TSMAFSPDSK
130 140 150 160 170 180
YLLTQTSPPD SNLVYWLWEK QKVMAIIKAD SQNNPIYQVS ISSQDNSQVC ITGSGVFKLL
190 200 210 220 230 240
RFAEGTLKQI NFQRGESSNY LAHAWVSEDR VIVGTDTGKL FLFESGDQRW ETSIMVKEST
250 260 270 280 290 300
SSRSLEVIQE SESLIEFPPL SSPVSSVERM DITTNTQQQA MPQVFAIAAY SKGFACSAGP
310 320 330 340 350 360
GRVLLFEKVE EKDFYRESRE IRIPTDQQSN DPSQSDKQDV LCLCFSPSEE TLIASTNKNQ
370 380 390 400 410 420
LYSITMSLTE ISKGEAAHFE YLLYPLHSAS ITGLDTCIRK PLIATCSLDR SVRIWNYESN
430 440 450 460 470 480
TLELYKEYQE EAYTVSLHPS GHYIVVGFAD KLRLMNLLID DIRPFKEYSV RGCKECSFSN
490 500 510 520 530 540
GGHLFAAVNG NVIHIFTTTS LENINILKGH TGKIRSLVWN LDDSKLVSAG TDGAVYEWNL
550 560 570 580 590 600
STGKRETECV LKSCSYNSVT TSPDAKVIFA VGSDQTLKEI SDSLILREIP AFDVIYTSIT
610 620 630 640 650 660
ISHSGRMIFV GTSVGTIRAM KYPLSLQKEY NEYQAHAGPV MKMLLTFDDQ FLLTVGEDGC
670 680 690 700 710 720
LFTWKVFDKD GRGIKREREV GFAEEVLVTK TDMEEKAQIM LELKTRVEEL KMENEYQLRL
730 740 750 760 770 780
KDMNYTEKIK ELTDKFIQEM ESLKTKNQVL KTEKEKQDIS HRERLEELVD KQTRELQDLE
790 800 810 820 830 840
CCNNQKLLLE YEKYQELQLK SQRMQEEYEK QLRDNDETKS QALEELTEFY EAKLQEKTGL
850 860 870 880 890 900
LEEAQEDVRQ QLREFEETKK QIEEDEDREI QDIKTKYERK LRDEKESNLR LKGETGIMRK
910 920 930 940 950 960
KFSSLQKEIE ERTNDIELLK SEQMKLQGII RSLEKDIQGL KREIQERDET IQDKEKRIYD
970 980 990 1000 1010 1020
LKKKNQELEK FKFVLDYKIK ELKKQIEPRE NEIKVMKEQI QEMEAELERF HKQNTQLELN
1030 1040 1050 1060 1070 1080
ITELLQKLRA TDQEMRKEQQ KERDLEALVR RFKTDLHNCV AYIQEPGLLK EKIRGLFEKY
1090 1100 1110 1120 1130 1140
VQRADMVEIA GLNSDLQQEY ARQREHLERN LATLKKKVIK EGELHRTDYV RIMQENVSLI
1150 1160 1170 1180 1190 1200
KEINELRREL KLTRSQIYDL ESALKVSKKT RSQEVPESVI SKDVVGSTST MRLNEQEETG
1210 1220 1230 1240
RIIEMQRLEI RRLRDQIQEQ EQVPGFHTIA GVRLPSIVDS DVDFEVHTK