Q9CYT6
Gene name |
Cap2 |
Protein name |
Adenylyl cyclase-associated protein 2 |
Names |
CAP 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:67252 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9CYT6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9CYT6-F1 | Predicted | AlphaFoldDB |
19 variants for Q9CYT6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs253258461 | 2 | T>A | No | EVA | |
| rs221969025 | 4 | M>T | No | EVA | |
| rs3389273037 | 7 | L>M | No | EVA | |
| rs3389254816 | 33 | G>W | No | EVA | |
| rs220246885 | 42 | V>M | No | EVA | |
| rs3389296092 | 55 | S>T | No | EVA | |
| rs3389279223 | 80 | G>D | No | EVA | |
| rs3389281368 | 136 | V>I | No | EVA | |
| rs3389254902 | 190 | N>S | No | EVA | |
| rs3389272962 | 205 | T>P | No | EVA | |
| rs3389281893 | 206 | G>D | No | EVA | |
| rs3389281458 | 213 | G>S | No | EVA | |
| rs216705071 | 219 | A>V | No | EVA | |
| rs3389278499 | 242 | G>R | No | EVA | |
| rs225341195 | 276 | G>E | No | EVA | |
| rs225492448 | 306 | T>M | No | EVA | |
| rs3389291393 | 320 | H>D | No | EVA | |
| rs3389247902 | 365 | I>K | No | EVA | |
| rs3389210029 | 386 | H>D | No | EVA |
No associated diseases with Q9CYT6
7 regional properties for Q9CYT6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | CARP motif | 358 - 395 | IPR006599-1 |
| domain | CARP motif | 396 - 433 | IPR006599-2 |
| domain | Adenylate cyclase-associated CAP, C-terminal | 321 - 473 | IPR013912 |
| domain | Adenylate cyclase-associated CAP, N-terminal | 6 - 64 | IPR013992 |
| domain | C-CAP/cofactor C-like domain | 317 - 454 | IPR017901 |
| conserved_site | CAP, conserved site, N-terminal | 7 - 19 | IPR018106 |
| conserved_site | CAP, conserved site, C-terminal | 448 - 459 | IPR028417 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynaptic density | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| adenylate cyclase binding | Binding to an adenylate cyclase. |
| identical protein binding | Binding to an identical protein or proteins. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cAMP-mediated signaling | Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell. |
| cell morphogenesis | The developmental process in which the size or shape of a cell is generated and organized. |
| cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. |
| regulation of adenylate cyclase activity | Any process that modulates the frequency, rate or extent of adenylate cyclase activity. |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTDMAGLMER | LERAVIRLEQ | LSAGLDGPPR | GCGEVNGVNG | GVAPSVEAFD | KLINSMVAEF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LKNSRVLAGD | VETHAEMVHG | AFQAQRAFLL | MVSQYQQPQE | NEVAVLLKPI | SEKIQEIQTF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RERNRGSNMF | NHLSAVSESI | AALGWIAVSP | KPGPYVKEMN | DAATFYTNRV | LKDYKHSDLR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HVDWVRSYLN | IWSELQAYIR | EHHTTGLTWS | KTGPVASTAS | AFSILSSGPG | LPPPPPPPPP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PGPPPPFENE | DKKEEPSPSR | SALFAQLNQG | EAITKGLRHV | TDDKKTYKNP | SLRAQGQIRS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PTKTHTPSPT | SPKSNSPQKH | TPVLELEGKK | WRVEYQEDRN | DLVISETELK | QVAYIFKCDK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| STLQIKGKVN | SITVDNCKKF | GLVFDHVVGI | VEVINSKDIQ | IQVMGRVPTI | SINKTEGCHL |
| 430 | 440 | 450 | 460 | 470 | |
| YLSEDALDCE | IVSAKSSEMN | VLVPQDDDYR | EFPIPEQFKT | IWDGSKLVTE | PAEIMA |