AiPD: Autoinhibited Protein Database

Gene name	Dcp2
Protein name	m7GpppN-mRNA hydrolase
Names	mRNA-decapping enzyme 2
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:70640
EC number	3.6.1.62: In phosphorus-containing anhydrides
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

216-292 (Predicted disordered autoinhibitory region) PR

216-292 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9CYC6-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389479166	26	S>R	No	EVA
rs3389501712	38	Q>H	No	EVA
rs3389502979	58	P>L	No	EVA
rs3411602252	80	G>D	No	EVA
rs3389494925	84	E>D	No	EVA
rs3408121096	120	A>G	No	EVA
rs3408399200	121	K>E	No	EVA
rs3389501715	150	G>V	No	EVA
rs3389459085	184	T>S	No	EVA
rs3408121093	191	R>I	No	EVA
rs3389494894	191	R>S	No	EVA
rs3389468598	201	S>A	No	EVA
rs3389468567	245	D>E	No	EVA
rs30220684	300	S>P	No	EVA
rs3408499233	345	K>Q	No	EVA
rs3408473713	347	Q>H	No	EVA
rs3408499114	348	N>K	No	EVA
rs3408427519	349	P>L	No	EVA
rs3389494907	353	C>R	No	EVA
rs3389510012	392	A>V	No	EVA
rs266140979	405	A>T	No	EVA

Type	Name	Position	InterPro Accession
domain	Tyrosine-specific protein phosphatases domain	344 - 406	IPR000387
domain	Protein-tyrosine phosphatase, catalytic	323 - 471	IPR003595
domain	GRAM domain	29 - 143	IPR004182
domain	Myotubularin-like, phosphatase domain	151 - 538	IPR010569
active_site	Protein-tyrosine phosphatase, active site	373 - 383	IPR016130

		Description
EC Number	3.6.1.62	In phosphorus-containing anhydrides
Subcellular Localization	Cytoplasm, P-body Nucleus	Predominantly cytoplasmic, in processing bodies (PB) (By similarity) A minor amount is nuclear (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cell junction	A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic ribonucleoprotein granule	A ribonucleoprotein granule located in the cytoplasm.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
P-body	A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
RISC complex	A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation.

Name	Definition
5'-3' exoribonuclease activity	Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule.
m7G(5')pppN diphosphatase activity	Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide.
manganese ion binding	Binding to a manganese ion (Mn).
RNA binding	Binding to an RNA molecule or a portion thereof.

Name	Definition
deadenylation-dependent decapping of nuclear-transcribed mRNA	Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length.
histone mRNA catabolic process	The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA).
mRNA catabolic process	The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
negative regulation of telomere maintenance via telomerase	Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase.
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
regulation of mRNA stability	Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
regulation of telomerase RNA localization to Cajal body	Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins