AiPD: Autoinhibited Protein Database

Gene name	Blvra
Protein name	Biliverdin reductase A
Names	BVR A, Biliverdin-IX alpha-reductase
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:109778
EC number	1.3.1.24: With NAD(+) or NADP(+) as acceptor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

165-243 (Predicted disordered autoinhibitory region) PR

165-243 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9CY64-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs13470683	2	S>N	No	EVA
rs222788723	41	Y>F	No	EVA
rs3388587484	43	S>C	No	EVA
rs3388576368	47	L>F	No	EVA
rs3388585203	56	I>T	No	EVA
rs253763408	63	R>H	No	EVA
rs3388589592	68	D>E	No	EVA
rs3388589969	76	S>R	No	EVA
rs3388591733	77	S>P	No	EVA
rs3388589519	79	H>R	No	EVA
rs243059682	81	D>E	No	EVA
rs3388589967	82	Y>F	No	EVA
rs3392171005	84	R>G	No	EVA
rs3388591814	107	Q>R	No	EVA
rs246415834	110	W>C	No	EVA
rs3388582060	110	W>R	No	EVA
rs3388581762	114	A>T	No	EVA
rs3392045000	130	E>Q	No	EVA
rs3392206939	137	R>S	No	EVA
rs33061043	192	R>Q	No	EVA
rs256600810	211	P>T	No	EVA
rs240345036	227	H>Q	No	EVA
rs259407944	275	K>Q	No	EVA
rs47356914	278	L>M	No	EVA
rs27416343	282	E>G	No	EVA
rs3388586311	283	L>Q	No	EVA
rs229518904	293	R>Q	No	EVA

Type	Name	Position	InterPro Accession
domain	Homocysteine-binding domain	8 - 309	IPR003726

		Description
EC Number	1.3.1.24	With NAD(+) or NADP(+) as acceptor
Subcellular Localization	Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Name	Definition
biliberdin reductase NAD+ activity	Catalysis of the reaction: bilirubin + NAD+ = biliverdin + NADH+ H+.
biliverdin reductase (NAD(P)+) activity	Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+.
biliverdin reductase (NADP+) activity	Catalysis of the reaction: bilirubin + NADP+ = biliverdin + NADPH + H+.
nucleotide binding	Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
zinc ion binding	Binding to a zinc ion (Zn).

Name	Definition
heme catabolic process	The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins