Q9CY45
Gene name |
Eef1akmt1 |
Protein name |
EEF1A lysine methyltransferase 1 |
Names |
N(6)-adenine-specific DNA methyltransferase 2, Protein-lysine N-methyltransferase N6amt2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:68043 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9CY45
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9CY45-F1 | Predicted | AlphaFoldDB |
12 variants for Q9CY45
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389340110 | 5 | E>G | No | EVA | |
| rs3389315795 | 6 | D>N | No | EVA | |
| rs248577931 | 34 | R>G | No | EVA | |
| rs251015947 | 92 | L>F | No | EVA | |
| rs3389337642 | 100 | Y>C | No | EVA | |
| rs3389315856 | 117 | F>I | No | EVA | |
| rs49989486 | 129 | R>G | No | EVA | |
| rs3404385613 | 157 | I>G | No | EVA | |
| rs3389306253 | 175 | E>* | No | EVA | |
| rs3389333597 | 184 | K>R | No | EVA | |
| rs3389306265 | 192 | H>Y | No | EVA | |
| rs3389315830 | 198 | N>D | No | EVA |
No associated diseases with Q9CY45
9 regional properties for Q9CY45
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 201 - 250 | IPR001680-1 |
| repeat | WD40 repeat | 252 - 424 | IPR001680-2 |
| repeat | WD40 repeat | 426 - 468 | IPR001680-3 |
| repeat | WD40 repeat | 471 - 511 | IPR001680-4 |
| domain | LIS1 homology motif | 6 - 38 | IPR006594 |
| domain | CTLH, C-terminal LisH motif | 40 - 92 | IPR006595 |
| repeat | G-protein beta WD-40 repeat | 228 - 242 | IPR020472-1 |
| repeat | G-protein beta WD-40 repeat | 278 - 292 | IPR020472-2 |
| repeat | G-protein beta WD-40 repeat | 362 - 376 | IPR020472-3 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| methyltransferase activity | Catalysis of the transfer of a methyl group to an acceptor molecule. |
| nucleic acid binding | Binding to a nucleic acid. |
| protein-lysine N-methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| peptidyl-lysine methylation | The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5WRN3 | M142.8 | Protein-lysine N-methyltransferase M142.8 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSESEDDDIP | QLSSHTLAAL | QEFYAEQKQS | VNPRGDDKYN | VGVIEENWQL | SQFWYSQDTA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LRLAREAIDA | AGEGGRIACV | SAPSVYQKLR | ELCREDSSVY | IFEYDRRFAI | YGDEFIFYDY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NHPLELPERI | AAHSFDLVVA | DPPYLSEECL | RKTSETIQFL | TRGKILLCTG | AIMEEQAAQL |
| 190 | 200 | 210 | |||
| LGVKMCKFIP | EHSRNLANEF | RCYTNYDSGL | DCEA |