AiPD: Autoinhibited Protein Database

Gene name	Tmem175
Protein name	Endosomal/lysosomal potassium channel TMEM175
Names	Transmembrane protein 175, mTMEM175
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:72392
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-49 (Predicted disordered autoinhibitory region) PR

1-49 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9CXY1-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3396020856	41	L>M	No	EVA
rs3395315543	41	L>Q	No	EVA
rs3395942747	42	S>P	No	EVA
rs3388778077	80	M>K	No	EVA
rs3388775265	102	I>T	No	EVA
rs3388782918	109	L>F	No	EVA
rs3388769342	113	C>S	No	EVA
rs3388772936	143	C>S	No	EVA
rs3388771727	143	C>S	No	EVA
rs3388778317	150	V>M	No	EVA
rs3388775272	170	Q>L	No	EVA
rs213843744	231	L>F	No	EVA
rs221259832	241	D>N	No	EVA
rs3395969543	292	F>V	No	EVA
rs3388780453	293	S>N	No	EVA
rs3388778324	295	S>N	No	EVA
rs3388769326	341	L>F	No	EVA
rs3395904793	359	T>A	No	EVA
rs3395629863	362	F>V	No	EVA
rs3388748212	375	V>I	No	EVA
rs3388761762	444	I>V	No	EVA
rs226758244	490	A>T	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9CXY1

		Description
EC Number
Subcellular Localization	Endosome membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endosome	A vacuole to which materials ingested by endocytosis are delivered.
integral component of endosome membrane	The component of the endosome membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of lysosomal membrane	The component of the lysosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
lysosome	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

Name	Definition
potassium channel activity	Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
potassium ion leak channel activity	Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state.

Name	Definition
neuron cellular homeostasis	The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state.
phagosome-lysosome fusion	The creation of a phagolysosome from a phagosome and a lysosome.
potassium ion transmembrane transport	A process in which a potassium ion is transported from one side of a membrane to the other.
regulation of lysosomal lumen pH	Any process that modulates the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins