Q9CWV0

PR
Gene name
Malsu1
Protein name
Mitochondrial assembly of ribosomal large subunit protein 1
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:75593
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

15-114 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9CWV0

Entry ID Method Resolution Chain Position Source
AF-Q9CWV0-F1 Predicted AlphaFoldDB

10 variants for Q9CWV0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3396795635 3 P>PCATAAAINAARATSPDP* No EVA
rs254324717 12 W>C No EVA
rs213688034 24 A>P No EVA
rs230158195 28 M>V No EVA
rs252292113 29 A>T No EVA
rs219729239 45 R>G No EVA
rs234915212 60 H>Y No EVA
rs3388832585 104 C>Y No EVA
rs3388832532 151 V>I No EVA
rs219029052 171 I>V No EVA

No associated diseases with Q9CWV0

No regional properties for Q9CWV0

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9CWV0

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion matrix
  • Colocalizes with MRPL12 and/or MRPL14
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrial large ribosomal subunit The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

1 GO annotations of molecular function

Name Definition
ribosomal large subunit binding Binding to a large ribosomal subunit.

4 GO annotations of biological process

Name Definition
negative regulation of mitochondrial translation Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.
negative regulation of ribosome biogenesis Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.
negative regulation of translation Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
ribosomal large subunit biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96EH3 MALSU1 Mitochondrial assembly of ribosomal large subunit protein 1 Homo sapiens (Human) PR
10 20 30 40 50 60
MGPGWSPARR LWPLLWRRAV FQRAGPAMAS VPWLPRLAER WLPARPATCL TPSLTRGLHH
70 80 90 100 110 120
GPQPEERTAG DARLQPGPAD HIGAKFDIDM LVSLLRQENA RDICVIQVPP EMRYTDYFVI
130 140 150 160 170 180
GSGTSTRHLH AMVHYLVKMY KHLKCRSDPY VKIEGKDADD WLCVDFGSMV IHLMLPETRE
190 200 210 220
TYELEKLWTL RSFDDQLAQI AAETLPEDFI LGLEDDTSSL TPVEFKCK