Q9CWT2

PR
Gene name
Bex4
Protein name
Protein BEX4
Names
Brain-expressed X-linked protein 4
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:406217
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-118 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9CWT2

Entry ID Method Resolution Chain Position Source
AF-Q9CWT2-F1 Predicted AlphaFoldDB

7 variants for Q9CWT2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3412224536 3 S>Y No EVA
rs3389575391 63 A>V No EVA
rs584720718 75 G>A No EVA
rs3412093325 92 T>A No EVA
rs578709525 93 T>K No EVA
rs581114443 100 Y>S No EVA
rs3389574214 118 P>S No EVA

No associated diseases with Q9CWT2

No regional properties for Q9CWT2

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9CWT2

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton, spindle pole
  • Nucleus
  • Cytoplasm
  • Also localizes to microtubules
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

2 GO annotations of molecular function

Name Definition
alpha-tubulin binding Binding to the microtubule constituent protein alpha-tubulin.
histone deacetylase binding Binding to histone deacetylase.

5 GO annotations of biological process

Name Definition
chromosome segregation The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
negative regulation of tubulin deacetylation Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylation.
regulation of cell migration Any process that modulates the frequency, rate or extent of cell migration.
regulation of cell population proliferation Any process that modulates the frequency, rate or extent of cell proliferation.
regulation of mitotic cell cycle Any process that modulates the rate or extent of progress through the mitotic cell cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MASKFKQVIL DLTVEKDKKD KKGGKASKQS EEEPHHLEEV ENKKPGGNVR RKVRRLVPNF
70 80 90 100 110
LWAIPNRHVD RNEGGEDVGR FVVQGTEVKR KTTEQQVRPY RRFRTPEPDN HYDFCLIP