Q9CWP8

PR
Gene name
Pold4
Protein name
DNA polymerase delta subunit 4
Names
DNA polymerase delta subunit p12
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:69745
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-67 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9CWP8

Entry ID Method Resolution Chain Position Source
AF-Q9CWP8-F1 Predicted AlphaFoldDB

1 variants for Q9CWP8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3406960282 78 L>F No EVA

No associated diseases with Q9CWP8

No regional properties for Q9CWP8

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9CWP8

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Partially recruited to DNA damage sites within 2 hours following UV irradiation, before degradation
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
delta DNA polymerase complex A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
DNA synthesis involved in DNA repair Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template.
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.
positive regulation of endothelial cell proliferation Any process that activates or increases the rate or extent of endothelial cell proliferation.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3T0X9 POLD4 DNA polymerase delta subunit 4 Bos taurus (Bovine) PR
Q9HCU8 POLD4 DNA polymerase delta subunit 4 Homo sapiens (Human) PR
10 20 30 40 50 60
MGRKRFITDS YPVVKKREGP PGHSKGELAP ELGEDTQSLS QEETELELLR QFDLAWQYGP
70 80 90 100
CTGITRLQRW SRAEQMGLKP PLEVYQVLKA HPEDPHFQCS LWHLYPL