AiPD: Autoinhibited Protein Database

Gene name	Riok2
Protein name	Serine/threonine-protein kinase RIO2
Names	RIO kinase 2
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:67045
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

397-469 (Predicted disordered autoinhibitory region) PR

397-469 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9CQS5-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389426528	28	K>N	No	EVA
rs237332378	78	A>V	No	EVA
rs3389414845	117	G>A	No	EVA
rs259400584	120	L>F	No	EVA
rs3389429288	127	L>I	No	EVA
rs3389404109	127	L>P	No	EVA
rs3389348415	136	K>I	No	EVA
rs3389383997	147	N>S	No	EVA
rs3389433093	156	L>F	No	EVA
rs3389450402	164	Y>F	No	EVA
rs3389348459	200	H>Y	No	EVA
rs3389429305	221	N>K	No	EVA
rs3389450467	233	N>K	No	EVA
rs3389433450	236	L>S	No	EVA
rs3389429032	236	L>V	No	EVA
rs1134284129	259	E>*	No	EVA
rs1134647639	259	E>A	No	EVA
rs3389429256	263	D>N	No	EVA
rs3389384017	270	R>L	No	EVA
rs3389452477	276	R>C	No	EVA
rs3389429023	294	D>G	No	EVA
rs3389436203	311	A>E	No	EVA
rs33763300	320	G>V	No	EVA
rs3389437468	329	E>D	No	EVA
rs3389404122	330	E>K	No	EVA
rs230369231	331	D>E	No	EVA
rs3389404172	339	E>*	No	EVA
rs264661752	343	E>G	No	EVA
rs227186888	360	D>G	No	EVA
rs244762717	363	G>R	No	EVA
rs237739048	365	S>P	No	EVA
rs48265164	369	S>L	No	EVA
rs3389433427	373	S>R	No	EVA
rs211735082	376	I>R	No	EVA
rs49928915	379	G>D	No	EVA
rs47492665	380	G>S	No	EVA
rs221756202	387	H>D	No	EVA
rs233887814	390	S>G	No	EVA
rs33763298	392	E>Q	No	EVA
rs3389441531	394	T>M	No	EVA
rs47958305	402	E>D	No	EVA
rs3389429025	402	E>K	No	EVA
rs3389446680	405	R>K	No	EVA
rs245210198	411	R>G	No	EVA
rs3389394850	418	E>D	No	EVA
rs240036308	502	R>C	No	EVA
rs3389433059	515	R>W	No	EVA
rs3389436222	517	Q>R	No	EVA
rs236381211	522	N>S	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9CQS5

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
preribosome, small subunit precursor	A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding	Binding to a metal ion.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

Name	Definition
maturation of SSU-rRNA	Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule.
positive regulation of ribosomal small subunit export from nucleus	Any process that activates or increases the frequency, rate or extent of ribosomal small subunit export from nucleus.
positive regulation of rRNA processing	Any process that activates or increases the frequency, rate or extent of rRNA processing.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
regulation of mitotic metaphase/anaphase transition	Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
ribosomal small subunit biogenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9BVS4	RIOK2	Serine/threonine-protein kinase RIO2	Homo sapiens (Human)	PR