Q9CQM0

PR
Gene name
Nicn1
Protein name
Nicolin-1
Names
Tubulin polyglutamylase complex subunit 5, PGs5, p24
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:66257
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

124-202 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9CQM0

Entry ID Method Resolution Chain Position Source
AF-Q9CQM0-F1 Predicted AlphaFoldDB

7 variants for Q9CQM0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389074675 6 V>M No EVA
rs3389069838 15 A>P No EVA
rs3389052245 18 V>M No EVA
rs3400648703 45 L>VFPAQKP*SLIWGVAHLERRD No EVA
rs3389071621 104 M>T No EVA
rs3389082272 147 F>I No EVA
rs3389048732 194 T>M No EVA

No associated diseases with Q9CQM0

No regional properties for Q9CQM0

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9CQM0

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

No GO annotations of biological process

Name Definition
No GO annotations for biological process

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q861Y6 NICN1 Nicolin-1 Canis lupus familiaris (Dog) (Canis familiaris) PR
Q9BSH3 NICN1 Nicolin-1 Homo sapiens (Human) PR
10 20 30 40 50 60
MSRVLVPCHV KSTVALQVGD MRTSQGRPGV LVVDVTFPNI APFELQEIMF KNYYTAFLSI
70 80 90 100 110 120
RVRQQSSMHT AAKWVTCLRD YCLMPDPHSE EGAQDYVSLF KHQMLCDMNR VLELRLILRQ
130 140 150 160 170 180
PSPLWLSFTV EELQIYQQGP KSPSLAFPKW LSHPVSNEQP APRLEGLPDP SRVSSEVQQM
190 200 210
WALTEMIRAS HTSTRIGRFD VDGCYDLNLL SYT