Q9CQC7

PR
Gene name
Ndufb4
Protein name
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
Names
Complex I-B15, CI-B15, NADH-ubiquinone oxidoreductase B15 subunit
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:68194
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-61 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

14 structures for Q9CQC7

Entry ID Method Resolution Chain Position Source
6G2J EM 330 A m 1-129 PDB
6G72 EM 390 A m 1-129 PDB
6ZR2 EM 310 A m 1-129 PDB
6ZTQ EM 300 A m 1-129 PDB
7AK5 EM 317 A m 1-129 PDB
7AK6 EM 382 A m 1-129 PDB
7B93 EM 304 A m 1-129 PDB
7PSA EM 340 A m 1-129 PDB
8C2S EM 390 A m 1-129 PDB
8CA3 EM 320 A m 1-129 PDB
8CA5 EM 390 A m 1-129 PDB
8OLT EM 284 A m 1-129 PDB
8OM1 EM 239 A m 1-129 PDB
AF-Q9CQC7-F1 Predicted AlphaFoldDB

2 variants for Q9CQC7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs262754643 25 V>L No EVA
rs219467922 114 R>K No EVA

No associated diseases with Q9CQC7

No regional properties for Q9CQC7

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9CQC7

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Single-pass membrane protein ; Matrix side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial respiratory chain complex I A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name Definition
aerobic respiration The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.
mitochondrial respiratory chain complex I assembly The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I.
proton motive force-driven mitochondrial ATP synthesis The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis.
response to oxidative stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSGSKYKPAP LATLPSTLDP AEYDVSPETR RAQVERLSIR ARLKREYLLQ YNDPKRVSHI
70 80 90 100 110 120
EDPALIRWTY ARSANIYPNF RPTPKNSLLG AVAGFGPLIF WYYVFKTDRD RKERLIQEGK
LDRKFNISY