Q9CMQ8

PR
Gene name
tyrS
Protein name
Tyrosine--tRNA ligase
Names
Tyrosyl-tRNA synthetase, TyrRS
Species
Pasteurella multocida (strain Pm70)
KEGG Pathway
pmu:PM0755
EC number
6.1.1.1: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

276-387 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9CMQ8

Entry ID Method Resolution Chain Position Source
AF-Q9CMQ8-F1 Predicted AlphaFoldDB

No variants for Q9CMQ8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9CMQ8

No associated diseases with Q9CMQ8

3 regional properties for Q9CMQ8

Type Name Position InterPro Accession
domain Oxoglutarate/iron-dependent dioxygenase 158 - 259 IPR005123
domain Non-haem dioxygenase N-terminal domain 11 - 100 IPR026992
domain Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain 165 - 259 IPR044861

Functions

Description
EC Number 6.1.1.1 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
RNA binding Binding to an RNA molecule or a portion thereof.
tyrosine-tRNA ligase activity Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTEINTVLAE LKRGVDEILS EADLIEKLKE NRPLRVKLGA DPTAPDIHLG HTVVLNKLRQ
70 80 90 100 110 120
FQQFGHEVIF LIGDFTGMVG DPSGKNTTRP PLSRDDVLRN AETYKQQIYK ILDPQKTRIV
130 140 150 160 170 180
FNSSWLGELG TEGMIRLTSN YTVARMLERD DFKKRFSNNQ PIAIHEFIYP LLQGYDSVAL
190 200 210 220 230 240
DADIELGGTD QKFNLLVGRE LQKSAGQKPQ VAITLPLLVG LDGEKKMSKS LGNYIGVAES
250 260 270 280 290 300
PTEMFGKVMS ISDELMWDWY DLLSFRPLTE IAQLKQEVEN GRNPRDIKVL LAKELIARFH
310 320 330 340 350 360
SEADAEAAEQ EFINRFQKGA MPEDMPELTF EGEMGLANLL KEAGLVASTS EANRMVQQGG
370 380 390
VKIDGEKVED AKLVIKASTA VYQVGKRKFA RVTVK