Q9CLB8

PR
Gene name
mltC
Protein name
Membrane-bound lytic murein transglycosylase C
Names
Murein lyase C
Species
Pasteurella multocida (strain Pm70)
KEGG Pathway
pmu:PM1321
EC number
4.2.2.n1: Acting on polysaccharides
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

216-289 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9CLB8

Entry ID Method Resolution Chain Position Source
AF-Q9CLB8-F1 Predicted AlphaFoldDB

No variants for Q9CLB8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9CLB8

No associated diseases with Q9CLB8

3 regional properties for Q9CLB8

Type Name Position InterPro Accession
active_site Prokaryotic transglycosylase, active site 211 - 239 IPR000189
domain Transglycosylase SLT domain 1 194 - 317 IPR008258
domain Murein transglycosylase-C, N-terminal 29 - 188 IPR024570

Functions

Description
EC Number 4.2.2.n1 Acting on polysaccharides
Subcellular Localization
  • Cell outer membrane ; Lipid-anchor
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cell outer membrane A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

3 GO annotations of molecular function

Name Definition
hydrolase activity, acting on glycosyl bonds Catalysis of the hydrolysis of any glycosyl bond.
lyase activity Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
lytic transglycosylase activity Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues.

3 GO annotations of biological process

Name Definition
cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall.
cell wall organization A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
peptidoglycan metabolic process The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of strands of glycosaminoglycan cross-linked by oligopeptides to form a huge and rigid network.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKKYIIYALI PFLFACGGTK THRSSQFDEA FAKDTRGLDI LTGQFSHNID RIWGVNELLV
70 80 90 100 110 120
ASRKDYVKYT DRFYTRSHVS FDEGLITVET QSDLRHLQNA IVHILLMGSD ANGIDLFASG
130 140 150 160 170 180
DVPISSRPFL VGQVIDHLGG SITNTTTAGN FANYLLQNKL QTRRLSNGHT VQYVVIPMIA
190 200 210 220 230 240
NHVAVRAQRY LPLVRKMARR YNMDESLILG IMQTESSFNP YAISYANAIG LMQVVPTTAG
250 260 270 280 290 300
RDIFKMKGKG GQPSKSYLFD PEKNIDAGTS YLWLLQNKYL DGITNPTSKR FAMISAYNSG
310 320 330 340 350
AGAVLRVFDQ DRDAAIVKIN SLYPEQVYRI LTTQHPSAQA RNYLLKVDQA QKSYRVRR