Q9CKF7

PR
Gene name
ileS
Protein name
Isoleucine--tRNA ligase
Names
Isoleucyl-tRNA synthetase, IleRS
Species
Pasteurella multocida (strain Pm70)
KEGG Pathway
pmu:PM1662
EC number
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

791-864 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9CKF7

Entry ID Method Resolution Chain Position Source
AF-Q9CKF7-F1 Predicted AlphaFoldDB

No variants for Q9CKF7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9CKF7

No associated diseases with Q9CKF7

4 regional properties for Q9CKF7

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 59 - 70 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 29 - 641 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 686 - 842 IPR013155
domain Isoleucyl tRNA synthetase type 1, anticodon-binding domain 641 - 821 IPR033708

Functions

Description
EC Number 6.1.1.5 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
isoleucine-tRNA ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTVDYKNTLN LPETGFPMRG DLAKREPNML KSWYEKDLYQ KIRQASKGKK SFILHDGPPY
70 80 90 100 110 120
ANGTIHIGHA VNKILKDIIV KSKTALGYDS PYIPGWDCHG LPIELKVEGL VGKPNQNISA
130 140 150 160 170 180
AQFREACRQY AAEQVEGQKK DFIRLGVLGD WDNPYLTMNY HTEANIIRAF GKAVENGHLY
190 200 210 220 230 240
KGSKPVHWCL DCASSLAEAE VEYEDKVSPS IYVRFSAVDS DAVLAKFNAT DKGTGNISAV
250 260 270 280 290 300
IWTTTPWTIP SNRAIAIHEN LDYQLVQFND ERVILAKDLV EEVAKAAGVE QVVILGESKG
310 320 330 340 350 360
KDLEWLRFQH PFYDFSVPFI LGDHVTTDGG TGLVHTAPDH GHDDYIIAQK NGIEMAGLIG
370 380 390 400 410 420
NDGLFKADVP FFAGKGVFES NDLVVAKLQE VGAMLKFSKI KHSYPHCWRH KTPIIFRATP
430 440 450 460 470 480
QWFIGMEKQG LRQQALSEIK KVRWIPDWGQ ARIEKMVENR PDWCISRQRT WGVPVALFIH
490 500 510 520 530 540
KETEELHPRT VELVEEVAKR VEQKGIQAWW DLDTAELLGA DADNYIKVPD TLDVWFDSGS
550 560 570 580 590 600
TYYSVVKDRP EFNGQEADMY LEGSDQHRGW FMSSLMLSTA TDNKAPYKQV LTHGFTVDGQ
610 620 630 640 650 660
GRKMSKSIGN IVTPQEVMDK FGGDILRLWV ASTDYTGEIS VSDEILKRAA DAYRRIRNTA
670 680 690 700 710 720
RFLLANLNGF DPKRDLVKPE EMMVLDRWAV DCAYQAQNEI KDAYDNYQFH AVIQRLMKFC
730 740 750 760 770 780
SIEMGSFYLD IIKDRQYTTK ADSLARRSCQ TALWHIAEAL VRWIAPVLSF TADEIWQYIP
790 800 810 820 830 840
GERGEFVFTE EFYNGLFALD ANEQMNDAYW QQVITLRNEV NRVLEQARND KIIGAALEAE
850 860 870 880 890 900
LTIYANDTYA PLLAKLQNEL RFVLLTSKAE VKPLADADVA EGEVKGFAVK VVRSANHKCP
910 920 930
RCWHYSDSKD AESLCSRCDE NVNGQGEVRQ FA