Q9CIH5
Gene name |
tyrS |
Protein name |
Tyrosine--tRNA ligase |
Names |
Tyrosyl-tRNA synthetase, TyrRS |
Species |
Lactococcus lactis subsp lactis (strain IL1403) (Streptococcus lactis) |
KEGG Pathway |
lla:L0359 |
EC number |
6.1.1.1: Ligases forming aminoacyl-tRNA and related compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9CIH5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9CIH5-F1 | Predicted | AlphaFoldDB |
No variants for Q9CIH5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9CIH5 | |||||
No associated diseases with Q9CIH5
7 regional properties for Q9CIH5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | ABC transporter-like, ATP-binding domain | 420 - 656 | IPR003439-1 |
| domain | ABC transporter-like, ATP-binding domain | 1078 - 1316 | IPR003439-2 |
| domain | AAA+ ATPase domain | 447 - 639 | IPR003593-1 |
| domain | AAA+ ATPase domain | 1105 - 1299 | IPR003593-2 |
| domain | ABC transporter type 1, transmembrane domain | 62 - 385 | IPR011527-1 |
| domain | ABC transporter type 1, transmembrane domain | 756 - 1043 | IPR011527-2 |
| conserved_site | ABC transporter-like, conserved site | 559 - 573 | IPR017871 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.1.1.1 | Ligases forming aminoacyl-tRNA and related compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| tyrosine-tRNA ligase activity | Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tyrosyl-tRNA aminoacylation | The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNIFDELKAR | GLVFQTTDEA | ALSKALTEDM | VSYYVGYDPT | ADSLHLGNLV | LILTMKRLQM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AGHKPYALVG | GATGLIGDPS | FKDSERSLQT | KDTVTKWSGK | IRSQLERFLD | FENGENKAEM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TNNYNWFENL | TFIDFLRDVG | KHFTVNYMIS | KDSVKSRMES | GISYTEFAYQ | IMQGYDFYEL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NQLHNVTLQL | GGSDQWGNMT | AGTELLRRKA | NKQGHVITIP | LITDSTGKKF | GKSEGNAIWL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DADKTSPYEM | YQFWLNVDDA | DAVKMLKIFT | FLSLEEIAEI | EEQFEAARHE | RLAQKVLARE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VVSLVHGKAA | YEQAVKTSEI | LFGGGDLRQL | DAKSILTGLK | AAPQHQVTDD | EDLTLVELLI |
| 370 | 380 | 390 | 400 | 410 | |
| SAGIAPSKRQ | AREDITNGAI | YINGERVQAL | DYVITDSDKI | ENRLTVIRRG | KKKNFVLTY |