Q9CGE3

PR
Gene name
folKE (LL1154, L0175)
Protein name
Bifunctional protein FolKE
Names
Species
Lactococcus lactis subsp lactis (strain IL1403) (Streptococcus lactis)
KEGG Pathway
lla:L0175
EC number
2.7.6.3: Diphosphotransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

117-191 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9CGE3

Entry ID Method Resolution Chain Position Source
AF-Q9CGE3-F1 Predicted AlphaFoldDB

No variants for Q9CGE3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9CGE3

No associated diseases with Q9CGE3

3 regional properties for Q9CGE3

Type Name Position InterPro Accession
domain 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK 5 - 131 IPR000550
conserved_site GTP cyclohydrolase I, conserved site 227 - 243 IPR018234
domain GTP cyclohydrolase I domain 169 - 347 IPR020602

Functions

Description
EC Number 2.7.6.3 Diphosphotransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

6 GO annotations of molecular function

Name Definition
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H(+).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GTP binding Binding to GTP, guanosine triphosphate.
GTP cyclohydrolase I activity Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
zinc ion binding Binding to a zinc ion (Zn).

5 GO annotations of biological process

Name Definition
7,8-dihydroneopterin 3'-triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 7,8-dihydroneopterin 3'-triphosphate.
folic acid biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid, pteroylglutamic acid.
one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
tetrahydrofolate biosynthetic process The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQTTYLSMGS NIGDRQYYLH EAIRLLGKHP KIMIEKVSNF YESTPVGGVK QDDFTNLALK
70 80 90 100 110 120
VATLLEPLEL LSFIHEVELS LNRERKIHWG PRTIDIDIIF YDDLEMQVEN LVIPHKEAFN
130 140 150 160 170 180
RLFVLKPIFE LIDKDFKYYA SIEKAIAELS VSEQELHVIK EEKTPRNRIE DAVKEILFAV
190 200 210 220 230 240
GENPNREGLL ETPARVAKMY EEILSSQRLS KFNEYKLFEI DSSKTDSIVL IKDIPFYSMC
250 260 270 280 290 300
EHHMLPFFGK AHVAYIPADG KIIGLSKIPR LVDYVSRKLS VQENITHDIG DILTDILNPK
310 320 330 340
GVAVLVEGRH MCVEMRGVKK VNSITKTSYF LGEFKENNEK RMEFLESLL