Q9CG80

PR
Gene name
topA
Protein name
DNA topoisomerase 1
Names
DNA topoisomerase I, Omega-protein, Relaxing enzyme, Swivelase, Untwisting enzyme
Species
Lactococcus lactis subsp lactis (strain IL1403) (Streptococcus lactis)
KEGG Pathway
lla:L0298
EC number
5.6.2.1: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-57 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9CG80

Entry ID Method Resolution Chain Position Source
AF-Q9CG80-F1 Predicted AlphaFoldDB

No variants for Q9CG80

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9CG80

No associated diseases with Q9CG80

3 regional properties for Q9CG80

Type Name Position InterPro Accession
domain Terpene synthase, N-terminal domain 24 - 193 IPR001906
domain Terpene synthase, metal-binding domain 226 - 489 IPR005630
domain Terpene cyclase-like 1, C-terminal domain 226 - 545 IPR034741

Functions

Description
EC Number 5.6.2.1 Enzymes altering nucleic acid conformation
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA topoisomerase type I (single strand cut, ATP-independent) activity Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPTSTKSKTK TTTKKKTTRK RVTPGKNLVI VESPAKAKTI EKYLGRNYKV VASVGHIRDL
70 80 90 100 110 120
KKSTMSVDIE NDYEPQYINI RGKAPLINSL KKEAKAAKAV YLASDPDREG EAISWHLAHI
130 140 150 160 170 180
LNLPLEEKNR VVFNEITKDA VKNAFKEPRQ IDVDLVDAQQ ARRVLDRLVG YSISPILWKK
190 200 210 220 230 240
VKKGLSAGRV QSIALKLIVD RENEINAFIP EEYWSIDGEF KKGTKKFKAS FWGIDGKKHP
250 260 270 280 290 300
LKTNEDVIKV MERLDGPDFN VDKVEKKERR RNAPLPYTTS SMQQDAANKL NFRTRKTMMV
310 320 330 340 350 360
AQQLYEGLTL GSQGHQGLIT YMRTDSTRIS PVAQSAAHNY IADQFGEKYS KHGSKVKNAS
370 380 390 400 410 420
GAQDAHEAIR PSNVFNTPDA IAKYLDKDQL KLYTLIWNRF VASQMVAAIF DTVKVNLSQN
430 440 450 460 470 480
GVIFIANGSQ VKFDGYLRIY NDSDKSNMLP EMEENETVKK ANVKPEQHFT QPPARYSEAT
490 500 510 520 530 540
LIKTLEENGV GRPSTYAPTL ETIQKRYYVR LSAKRFEPTE LGEIVNKLIV EFFPNIVNTE
550 560 570 580 590 600
FTAEMEKDLD EVEEGKRQWI EVVDQFYKPF AKELENAEEG MEKIQIKDEP AGFDCDVCGS
610 620 630 640 650 660
PMVIKLGRFG KFYACSNFPD CRNTKAIVKE IGVKCPLCHE GNIIERKTKK NRIFYGCDRY
670 680 690 700
PDCEFTSWDK PIGRDCPKSG HFLVEKKVRG GGKQVVCSND ECDYQEEKQK