Q9CEW0

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Lactococcus lactis subsp lactis (strain IL1403) (Streptococcus lactis)
KEGG Pathway
lla:L0343
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

34-106 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9CEW0

Entry ID Method Resolution Chain Position Source
AF-Q9CEW0-F1 Predicted AlphaFoldDB

No variants for Q9CEW0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9CEW0

No associated diseases with Q9CEW0

5 regional properties for Q9CEW0

Type Name Position InterPro Accession
domain DHHA1 domain 736 - 869 IPR003156
domain Aminoacyl-tRNA synthetase, class II 62 - 255 IPR006195
domain Threonyl/alanyl tRNA synthetase, SAD 655 - 698 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 8 - 558 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 711 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKTMTSAEVR QMFLDFFKSK GHTVEPSQSL VPVNDPTLLW INSGVATLKK YFDGSVVPEN
70 80 90 100 110 120
PRLTNAQKAI RTNDIENVGK TARHHTMFEM LGNFSIGDYF RKEAIAFAWE LLTSSEWFEF
130 140 150 160 170 180
PAEKLYITYY PADKDTYNRW VEVGVDPTHL VPIEDNFWEI GAGPSGPDTE IFFDRGEVYD
190 200 210 220 230 240
PEHVGLKLLA EDIENDRYIE IWNIVLSQFN ADPSIPRSEY PELPQKNIDT GMGLERMVCI
250 260 270 280 290 300
IQGGKTNFDT DLFLPIIREI EKLSGKTYSP DSENMSFKVI ADHIRSLSFA IGDGALPGNE
310 320 330 340 350 360
GRGYVLRRLL RRAVMHGKKL GIQGKFLASL VPTVGKIMQS YYPEVLEKED FIMQIIDREE
370 380 390 400 410 420
ETFNRTIDAG QKLIDELLLN LKSEGKDRLE GADIFRLYDT YGFPVELTEE LAEDEGFKID
430 440 450 460 470 480
HEGFKVAMKA QQERARAAVV KGGSMGAQNE TLSSIEVESE FLYEDKTTQG KLLVSIQDDE
490 500 510 520 530 540
IVDEVSGKAQ LVFDVTPFYA EMGGQVADHG VIKDAEGQVV ANVLDVQHAP HGQNLHSVET
550 560 570 580 590 600
LSPLKVGESY TLEIDKERRA AVVKNHTATH LLHAALHNIV GNHALQAGSL NEVEFLRFDF
610 620 630 640 650 660
THFAQVTKEE LAEIERQVNE VIWQSLKVET VETDIATAKE MGAMALFGEK YGKNVRVVKI
670 680 690 700 710 720
GDYSIELCGG THTQTTSEIG LFKIVKEEGI GSGVRRIIAV TGQKAYEAFK DAENTLNEVA
730 740 750 760 770 780
TMVKAPQTSQ VLAKVTSLQD ELKTAQKEND ALAGKLAASQ SDEIFKNVQT AGSLNFIASE
790 800 810 820 830 840
VTVPDANGLR NLADIWKQKE LSDVLVLVAK IGEKVSLLVA SKSSDVKAGN LVKELAPFVD
850 860 870
GRGGGKPDMA MAGGSKAAGI PELLAAVAEK LA