Q9CDT4

PR
Gene name
proS
Protein name
Proline--tRNA ligase
Names
Prolyl-tRNA synthetase, ProRS
Species
Lactococcus lactis subsp lactis (strain IL1403) (Streptococcus lactis)
KEGG Pathway
lla:L0356
EC number
6.1.1.15: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

247-328 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9CDT4

Entry ID Method Resolution Chain Position Source
AF-Q9CDT4-F1 Predicted AlphaFoldDB

No variants for Q9CDT4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9CDT4

No associated diseases with Q9CDT4

6 regional properties for Q9CDT4

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 94 - 492 IPR002314
domain Anticodon-binding 524 - 611 IPR004154
domain Aminoacyl-tRNA synthetase, class II 48 - 502 IPR006195
domain YbaK/aminoacyl-tRNA synthetase-associated domain 295 - 411 IPR007214
domain Prokaryote proline-tRNA ligase core domain 17 - 215 IPR033730
domain Proline--tRNA ligase, anticodon binding domain 520 - 612 IPR044140

Functions

Description
EC Number 6.1.1.15 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
proline-tRNA ligase activity Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).

1 GO annotations of biological process

Name Definition
prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a methionine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKQSKMLIPT LREMPSDAQV ISHALLMRAG YVRQVSAGIY AYLPLANRVL EKLKNIMREE
70 80 90 100 110 120
FDEIGAVELL APSLLTADLW RESGRYDTYG EDLYKLKNRD NSDFILGPTH EETMTSLVRD
130 140 150 160 170 180
EITSYKKLPL NVYQIAPKFR DEKRPRYGLL RGREFLMKDG YSYHADQDSL DETYNDYKKA
190 200 210 220 230 240
YEKIFERAGL NFKPIIADAG AMGGKDSQEF IAITDDRINL EKWLVLSKNI TSIEEIPESV
250 260 270 280 290 300
LSEIKEELGK WLIAGEDTIV YAEGGDYAAN IEMASSQFEP NVAYTEELEL EKVATPGAKT
310 320 330 340 350 360
IDEVSKFLEI DEEQTVKTLV YHADDELVVV LLNGNDQLNE VKLTNYLGAS FIEAASEAEV
370 380 390 400 410 420
EEKFGAHFGS LGPIGLENVK IIADRKVEQI KNAVVGANVD GFHYKNANFG RDYEVEEFVD
430 440 450 460 470 480
LRTVNEGEIS PDGRGTLKFA RGIEIGHIFK LGTRYTEAMN ANILDANGRS IPMLMGCYGI
490 500 510 520 530 540
GVSRLLSAIL EQFARIYVEK TPREEFKFSW SINFPKELAP FDIHLVPVNV KDEAAMELTS
550 560 570 580 590 600
ELEEKLRGKG YQVLVDDRNE RAGVKFADSD LIGLPVRVTI GKKAAEGVVE VKIRATGEVV
610
EINKDELVNT IEILSK