Q9CBW6

PR
Gene name
cobB
Protein name
NAD-dependent protein deacylase
Names
Regulatory protein SIR2 homolog
Species
Mycobacterium leprae (strain TN)
KEGG Pathway
mle:ML1511
EC number
2.3.1.286: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

173-237 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9CBW6

Entry ID Method Resolution Chain Position Source
AF-Q9CBW6-F1 Predicted AlphaFoldDB

No variants for Q9CBW6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9CBW6

No associated diseases with Q9CBW6

1 regional properties for Q9CBW6

Type Name Position InterPro Accession
domain Sirtuin family, catalytic core domain 1 - 235 IPR026590

Functions

Description
EC Number 2.3.1.286 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

6 GO annotations of molecular function

Name Definition
NAD+ binding Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
NAD-dependent protein deacetylase activity Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD.
protein-malonyllysine demalonylase activity Catalysis of the reaction: protein-malonyllysine + H2O => protein-lysine + malonate. This reaction is the removal of a malonyl group (CO-CH2-CO) from a malonylated lysine residue of a protein or peptide.
protein-succinyllysine desuccinylase activity Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl- + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-
transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
protein deacetylation The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRVVVLSGAG ISAESDVPTF RDDKNGLWAR FDPYQLSSTQ GWQRNPERVW GWYLWRHYLV
70 80 90 100 110 120
ANVKPNDGHR AIAAWQEQIE VSVITQNVDD LHERAGSTPV HHLHGSLFKF HCARCNVAYT
130 140 150 160 170 180
GALPDMPEPV LEVDPPVCYC GGLIRPAIVW FGEPLPDEPW RRAVEATETT DVMVVVGTSA
190 200 210 220 230
IVYPAAGLPE LALSRGAVVI EVNPEPTPLT KNATISIRET ASQALPGLLQ RLPALLK