AiPD: Autoinhibited Protein Database

Gene name	TOP6B
Protein name	DNA topoisomerase 6 subunit B
Names	AtTOP6B, Protein BRASSINOSTEROID INSENSITIVE 3, Protein ELONGATED HYPOCOTYL 6, Protein ROOT HAIRLESS 3
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT3G20780
EC number	5.6.2.2: Enzymes altering nucleic acid conformation
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-52 (Predicted disordered autoinhibitory region) PR

1-52 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9C5V6-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH10810895	21	N>D	No	1000Genomes
tmp_3_7268123_G_A	65	A>V	No	1000Genomes
tmp_3_7267688_T_G	129	N>T	No	1000Genomes
ENSVATH13955027	133	G>R	No	1000Genomes
ENSVATH05871945	139	P>S	No	1000Genomes
ENSVATH00336743	153	Y>F	No	1000Genomes
tmp_3_7266661_G_T	242	H>Q	No	1000Genomes
tmp_3_7266418_G_C	288	L>V	No	1000Genomes
tmp_3_7266398_C_G	294	E>D	No	1000Genomes
tmp_3_7266275_T_C	305	T>A	No	1000Genomes
ENSVATH10810834	342	L>V	No	1000Genomes
ENSVATH05871913	405	P>A	No	1000Genomes
ENSVATH05871909	432	Q>H	No	1000Genomes
ENSVATH10810793	495	Q>L	No	1000Genomes
tmp_3_7264552_G_C	555	Q>E	No	1000Genomes
ENSVATH13954974	569	T>M	No	1000Genomes
tmp_3_7264167_T_C	624	Y>C	No	1000Genomes
ENSVATH10810789	632	T>I	No	1000Genomes
ENSVATH00336734	638	E>D	No	1000Genomes
ENSVATH05871898	648	H>Y	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Histidine kinase/HSP90-like ATPase	48 - 227	IPR003594
domain	DNA topoisomerase VI, subunit B, transducer	398 - 557	IPR015320

		Description
EC Number	5.6.2.2	Enzymes altering nucleic acid conformation
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex	Complex that possesses DNA topoisomerase II (double strand cut, ATP-hydrolyzing) activity.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
small ribosomal subunit	The smaller of the two subunits of a ribosome.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.
identical protein binding	Binding to an identical protein or proteins.
protein homodimerization activity	Binding to an identical protein to form a homodimer.

Name	Definition
cell morphogenesis	The developmental process in which the size or shape of a cell is generated and organized.
DNA endoreduplication	Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes.
DNA topological change	The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
pattern specification process	Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.
response to brassinosteroid	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brassinosteroid stimulus.
trichome differentiation	The process in which a relatively unspecialized epidermal cell acquires the specialized features of a trichome cell. An example of this process is found in Arabidopsis thaliana.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q6H442	TOP6B	DNA topoisomerase 6 subunit B	Oryza sativa subsp japonica (Rice)	PR